Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.36 |
| ▸ | REN | P00797 | 2/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL5957028 | 1.00 | SLC7A5 (0.36) | SLC7A5RENSLC1A3SLC1A2DPP4 | |
| Leucine SCHEMBL28134392 | 1.00 | SLC7A5 (0.36) | SLC7A5RENSLC1A3SLC1A2DPP4 | |
| Leucine SCHEMBL8032136 | 0.96 | SLC7A5 (0.39) | SLC7A5RENSLC1A3SLC1A2DPP4 | |
| Leucine SCHEMBL8032138 | 0.96 | SLC7A5 (0.39) | SLC7A5RENSLC1A3SLC1A2DPP4 | |
| Leucine SCHEMBL1997233 | 0.94 | SLC7A5 (0.41) | SLC7A5RENSLC1A3SLC1A2DPP4 | |
| Leucine SCHEMBL1997232 | 0.94 | SLC7A5 (0.41) | SLC7A5RENSLC1A3SLC1A2DPP4 | |
| Leucine SCHEMBL4611635 | 0.94 | SLC7A5 (0.41) | SLC7A5RENSLC1A3SLC1A2DPP4 | |
| Leucine SCHEMBL18250039 | 0.93 | SLC7A5 (0.42) | SLC7A5RENSLC1A3SLC1A2DPP4 | |
| Isoleucine SCHEMBL4614661 | 0.93 | SLC7A5 (0.35) | SLC7A5DPP4 | |
| Leucine SCHEMBL4663987 | 0.92 | SLC7A5 (0.43) | SLC7A5RENSLC1A3SLC1A2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3904528-A1 | DP04 POLYMERASE VARIANTS | Stratos Genomics Inc. (US) | 2021-11-03 | — | — | EP | disclosed |
| EP-3056575-A1 | POLYMERASES FOR NUCLEOTIDE ANALOGUE INCORPORATION | Pacific Biosciences Of California, Inc. (US) | 2016-08-17 | — | — | EP | disclosed |
| CN-101365807-A | Polymerases for incorporation of nucleotide analogs | PACIFIC BIOSCIENCES CALIFORNIA (US) | 2009-02-11 | — | — | CN | disclosed |
| EP-1666604-A1 | Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof | The Scripps Research Institute (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2003084465-A2 | MODELING BIOLOGICAL SYSTEMS | SRI INTERNATIONAL, INC. (US) | 2003-10-16 | — | — | WO | disclosed |