Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2111402 | 0.77 | PRSS1 (0.51) | SMN1; SMN2HTTPRSS1 | |
| SCHEMBL2109971 | 0.64 | PRSS1 (0.56) | PRSS1USP7 | |
| SCHEMBL22246554 | 0.64 | SMN1; SMN2 (0.69) | SMN1; SMN2HTTMGLLLMNAF2 | |
| SCHEMBL1038642 | 0.64 | MGLL (0.70) | SMN1; SMN2HTTMGLLLMNAF2 | |
| SCHEMBL1036975 | 0.64 | SMN1; SMN2 (0.68) | SMN1; SMN2HTTMGLLLMNAF2 | |
| SCHEMBL23867518 | 0.63 | SMN1; SMN2 (0.52) | SMN1; SMN2HTTMGLLLMNAORAI1 | |
| SCHEMBL3042348 | 0.63 | SMN1; SMN2 (0.67) | SMN1; SMN2HTTMGLLLMNAF2 | |
| SCHEMBL2898158 | 0.62 | AVPR2 (0.50) | SMN1; SMN2HTTMGLLLMNAORAI1 | |
| SCHEMBL27645591 | 0.59 | SMN1; SMN2 (0.78) | SMN1; SMN2HTTMGLLLMNAF2 | |
| SCHEMBL1037100 | 0.59 | SMN1; SMN2 (0.61) | SMN1; SMN2HTTMGLLLMNAF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067202-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-05-28 | — | — | WO | disclosed |