Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048168 | 0.86 | ALDH1A1 (0.45) | ALDH1A1MAPTHTTGAAPKM | |
| SCHEMBL8044886 | 0.86 | MAPK8 (0.51) | ALDH1A1MAPTHTTGAAPKM | |
| SCHEMBL8045048 | 0.86 | MAPT (0.47) | ALDH1A1MAPTHTTGAAPKM | |
| SCHEMBL8034759 | 0.86 | MAPT (0.47) | ALDH1A1MAPTHTTGAAPKM | |
| SCHEMBL8049908 | 0.86 | ALDH1A1 (0.47) | ALDH1A1MAPTHTTGAAPKM | |
| SCHEMBL8046704 | 0.85 | ALDH1A1 (0.60) | ALDH1A1MAPTHTTGAAPKM | |
| SCHEMBL8050651 | 0.85 | MAPT (0.44) | ALDH1A1MAPTHTTGAAPKM | |
| SCHEMBL8032471 | 0.85 | MAPK8 (0.52) | ALDH1A1MAPTHTTGAAPKM | |
| SCHEMBL8050630 | 0.83 | MAPK8 (0.46) | ALDH1A1MAPTHTTGAAPKM | |
| SCHEMBL8032469 | 0.83 | RECQL (0.57) | ALDH1A1MAPTHTTGAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |