Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Meparfynol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.42 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meparfynol SCHEMBL1171790 | 0.87 | L3MBTL1 (0.35) | HMGCRCHRM1TBXA2RADRA1AL3MBTL1 | |
| Meparfynol SCHEMBL12864498 | 0.82 | — | — | |
| Meparfynol SCHEMBL547715 | 0.82 | — | — | |
| Meparfynol SCHEMBL78626 | 0.82 | — | — | |
| Meparfynol SCHEMBL28814077 | 0.79 | — | — | |
| Meparfynol SCHEMBL11215486 | 0.79 | — | — | |
| Glycine SCHEMBL28051006 | 0.77 | GLRA1 (0.56) | GLRA1SLC6A9OR51E2HMGCRCHRM1 | |
| Meparfynol SCHEMBL3459559 | 0.73 | TSHR (0.33) | MEN1ALDH1A1THRBKMT2A | |
| SCHEMBL31605870 | 0.69 | — | — | |
| Tert-Butylamine SCHEMBL29128848 | 0.69 | GLRA1 (0.67) | GLRA1SLC6A9OR51E2HMGCRCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051222-A | CANCER DIAGNOSIS; GENETIC ENGINEERING | HUMAN GENOME SCIENCES, INC. (US) | 2000-04-18 | — | — | US | disclosed |
| US-6033870-A | Human transmembrane protein | INCYTE PHARMACEUTICALS, INC. (US) | 2000-03-07 | — | — | US | disclosed |
| US-6010852-A | Human proton atpase subunit | INCYTE PHARMACEUTICALS, INC. (US) | 2000-01-04 | — | — | US | disclosed |
| US-5985287-A | POLYPEPTIDES COMPRISING AN IMMUNOGENIC PORTION OF A M. VACCAE PROTEIN AND DNA MOLECULES ENCODING SUCH POLYPEPTIDES, ADMINISTERING DELIPIDATED AND DEGLYCOLIPIDATED M. VACCAE CELLS. | GENESIS RESEARCH AND DEVELOPMENT CORPORATION LIMITED (NZ) | 1999-11-16 | — | — | US | disclosed |
| US-5932470-A | FOR DETECTION AND TREATMENT OF ALLERGIC DERMATITIS IN ANIMALS | HESKA CORPORATION (US) | 1999-08-03 | — | — | US | disclosed |
| US-5928941-A | NUCLEOTIDE SEQUENCES THAT ENCODE A ZINC FINGER PROTEIN WITH CONSERVED DOMAINS; ANTITUMOR AGENTS AND SUPPRESSORS OF HYPERPLASIAS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1999-07-27 | — | — | US | disclosed |
| US-5928915-A | NUCLEOTIDE SEQUENCES THAT CODES FOR A CYTOSOLIC ENZYME FROM CHINESE HAMSTER OVARIES; DIAGNOSIS, ANTIFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS, ANTITUBERCULAR AGENTS, AND VIRICIDES | GENENTECH, INC. (US) | 1999-07-27 | — | — | US | disclosed |
| US-5922566-A | POLYNUCLEOTIDE | INCYTE PHARMACEUTICALS, INC. (US) | 1999-07-13 | — | — | US | disclosed |
| US-5914393-A | NUCLEIC ACIDS CODING FOR JANUS FAMILY NORECEPTOR PROTEINS TYROSINE KINASE; ANTISENSE/ANTICARCINOGENIC/ANTIARTHRITIC ANTIDIABETIC AGENTS | INCYTE PHARMACEUTICALS, INC. (US) | 1999-06-22 | — | — | US | disclosed |
| US-5910442-A | NUCLEIC ACID CODING FOR SUBSTRATE OF PROTEIN KINASE C INSERTING IT INTO A EXPRESSION VECTOR; TRANSFORMING A HOST; ANTICARCINOGENIC AGENTS | MOUNT SINAI SCHOOL OF MEDICINE (US) | 1999-06-08 | — | — | US | disclosed |