Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 6/20 | 0.49 |
| ▸ | TLR1 | Q15399 | 6/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1616767 | 0.86 | ALDH1A1 (0.49) | TLR2TLR1ALDH1A1TSHRMAPK1 | |
| SCHEMBL8475128 | 0.84 | ALDH1A1 (0.50) | TLR2TLR1GPR35ALDH1A1TSHR | |
| SCHEMBL1617550 | 0.83 | ALDH1A1 (0.47) | TLR2TLR1ALDH1A1TSHRMAPT | |
| SCHEMBL1616714 | 0.83 | ALDH1A1 (0.47) | TLR2TLR1ALDH1A1HPGDMAPK1 | |
| SCHEMBL2625708 | 0.83 | TLR2 (0.47) | TLR2TLR1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL512865 | 0.81 | PSEN1 (0.50) | HTT | |
| SCHEMBL10153120 | 0.81 | ALDH1A1 (0.49) | TLR2TLR1ALDH1A1TSHRMAPK1 | |
| SCHEMBL23292585 | 0.81 | TLR2 (0.49) | TLR2TLR1ALDH1A1TSHRTP53 | |
| SCHEMBL1038330 | 0.80 | ALDH1A1 (0.54) | TLR2TLR1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16914219 | 0.80 | TLR2 (0.44) | TLR2TLR1ALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108766-A1 | GAMMA SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER ' S DISEASE | SCHERING CORPORATION (US) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009076337-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2009-06-18 | — | — | WO | disclosed |