Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051212 | 0.83 | NPC1 (0.61) | NPC1RAB9ATLR9AGTR1MEN1 | |
| SCHEMBL8044168 | 0.82 | MAPK8 (0.44) | NPC1RAB9ATLR9AGTR1MEN1 | |
| SCHEMBL8041815 | 0.78 | MEN1 (0.33) | NPC1RAB9ATLR9AGTR1MEN1 | |
| SCHEMBL8048372 | 0.76 | MEN1 (0.33) | NPC1RAB9ATLR9AGTR1MEN1 | |
| SCHEMBL8042307 | 0.75 | MAPK8 (0.52) | NPC1RAB9ATLR9AGTR1MEN1 | |
| SCHEMBL7823341 | 0.75 | TDP1 (0.56) | NPC1RAB9ATLR9AGTR1MEN1 | |
| SCHEMBL8042806 | 0.75 | MAPK8 (0.52) | NPC1RAB9ATLR9AGTR1MEN1 | |
| SCHEMBL8050072 | 0.75 | NPC1 (0.57) | NPC1RAB9ATLR9AGTR1MEN1 | |
| SCHEMBL8033463 | 0.74 | MAPK8 (0.64) | NPC1RAB9ATLR9AGTR1MEN1 | |
| SCHEMBL8042859 | 0.74 | MAPK8 (0.57) | NPC1RAB9ATLR9AGTR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |