SCHEMBL8034216

SCHEMBL8034216

CCCC1CCC(CCCCc2ccc(C(F)(F)F)c(F)c2)CC1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.40
KIF11 P52732 2/20 0.38
KDM1A O60341 1/20 0.35
SLC6A2 P23975 1/20 0.34
SLC6A4 P31645 1/20 0.34
SLC6A3 Q01959 1/20 0.34
HRH3 Q9Y5N1 1/20 0.34
BCHE P06276 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C8 P10632 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
S1PR3 Q99500 1/20 0.34
ITGB3 P05106 1/20 0.33
ITGA2B P08514 1/20 0.33
EPHX2 P34913 1/20 0.33
MOGAT2 Q3SYC2 1/20 0.33
FFAR1 O14842 1/20 0.33
CNR2 P34972 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8747925 0.95 DAO (0.40) DAOKIF11BCHECYP3A4CYP2C8
SCHEMBL8030794 0.95 DAO (0.40) DAOKIF11KDM1AHRH3BCHE
SCHEMBL8748064 0.93 CYP3A4 (0.40) DAOKIF11SLC6A2SLC6A4SLC6A3
SCHEMBL8747900 0.93 CYP3A4 (0.40) DAOKIF11SLC6A2SLC6A4SLC6A3
SCHEMBL8747948 0.93 CYP3A4 (0.40) DAOKIF11SLC6A2SLC6A4SLC6A3
SCHEMBL8031328 0.90 DAO (0.43) DAOKIF11KDM1ASLC6A2SLC6A4
SCHEMBL8029837 0.89 DAO (0.40) DAOKIF11KDM1ASLC6A2SLC6A4
SCHEMBL8748214 0.89 DAO (0.42) DAOKIF11KDM1ASLC6A2SLC6A4
SCHEMBL8028367 0.88 CYP3A4 (0.40) DAOKIF11KDM1ASLC6A2SLC6A4
SCHEMBL8747944 0.88 DAO (0.40) DAOKIF11KDM1ASLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6013198-A LIQUID CRYSTALLINE COMPOUNDS MODIFIED TO HAVE A TRIFLUOROMETHYLPHENYL GROUP OR TRIFLUOROMETHOXYPHENYL GROUP AS EXAMPLE OF KNOWN TERMINAL SUBSTITUENT; CHEMICAL STABILITY, HIGH VOLTAGE HOLDING RATIO, GOOD UV STABILITY CHISSO CORPORATION (JP) 2000-01-11 US disclosed
EP-0761799-A1 Liquid crystalline compound substituted with fluorine containing group, liquid crystal composition, and liquid crystal display device Chisso Corporation (JP) 1997-03-12 EP disclosed