Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8034699 | 0.89 | MAPT (0.47) | MAPTALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL8036084 | 0.86 | MAPT (0.69) | MAPTALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL8025153 | 0.84 | MAPT (0.53) | MAPTALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL8034946 | 0.83 | MAPT (0.56) | MAPTALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL8038545 | 0.82 | ALDH1A1 (0.55) | MAPTALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL8038644 | 0.81 | MAPT (0.56) | MAPTALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL4012059 | 0.80 | MAPT (0.70) | MAPTALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL8034729 | 0.79 | MAPT (0.55) | MAPTALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL8020524 | 0.78 | DYRK1A (0.67) | MAPTALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL8040991 | 0.77 | DYRK1A (0.57) | MAPTALDH1A1RAB9ANPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |