Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PPIA | P62937 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1476176 | 0.79 | SLC6A2 (0.48) | SIGMAR1CHRM1CHRM3NPC1ALDH1A1 | |
| SCHEMBL4693545 | 0.78 | EPHX2 (0.71) | SIGMAR1ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1474677 | 0.78 | SLC6A2 (0.47) | SIGMAR1CHRM1CHRM3NPC1ALDH1A1 | |
| SCHEMBL9890798 | 0.78 | SIGMAR1 (0.55) | SIGMAR1CHRM1CHRM3HPGDALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5037785 | 0.77 | SLC6A2 (0.46) | SIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL12748513 | 0.77 | SLC6A2 (0.43) | SIGMAR1CHRM1CHRM3ALDH1A1 | |
| Acetic Acid SCHEMBL4305813 | 0.76 | CHRM1 (0.51) | SIGMAR1CHRM1CHRM3ALDH1A1L3MBTL1 | |
| SCHEMBL8023923 | 0.76 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL3638096 | 0.76 | SIGMAR1 (0.58) | SIGMAR1NPC1ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1475022 | 0.75 | SLC6A2 (0.42) | SIGMAR1CHRM1CHRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000071171-A2 | SIGMA-1 LIGANDS FOR DETERMINING CARCINOMA PROLIFERATIVE STATUS | WAKE FOREST UNIVERSITY (US) | 2000-11-30 | — | — | WO | disclosed |