Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | EBP | Q15125 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.32 |
| ▸ | MGLL | Q99685 | 2/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | GUSB | P08236 | 2/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18838747 | 0.78 | NPC1 (0.44) | NPC1RAB9AALDH1A1MEN1MAPT | |
| SCHEMBL4270831 | 0.76 | TSHR (0.47) | NPC1RAB9AALDH1A1MEN1MAPT | |
| SCHEMBL6750459 | 0.76 | TSHR (0.47) | ALDH1A1MEN1KMT2AEBPSIGMAR1 | |
| SCHEMBL4274617 | 0.76 | TSHR (0.47) | NPC1RAB9AALDH1A1MEN1MAPT | |
| SCHEMBL4355091 | 0.76 | TSHR (0.47) | ALDH1A1MEN1KMT2AEBPSIGMAR1 | |
| SCHEMBL4367088 | 0.76 | TSHR (0.47) | ALDH1A1MEN1KMT2AEBPSIGMAR1 | |
| SCHEMBL2701172 | 0.72 | TSHR (0.42) | ALDH1A1MEN1KMT2AEBPSIGMAR1 | |
| SCHEMBL19292785 | 0.72 | ALDH1A1 (0.36) | ALDH1A1EBPSIGMAR1LMNAHTT | |
| SCHEMBL7204901 | 0.72 | NPC1 (0.41) | NPC1RAB9AALDH1A1MEN1MAPT | |
| SCHEMBL665738 | 0.72 | NPC1 (0.43) | NPC1RAB9AALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831087-B1 | Process for the preparation of 1-acyl-4-arylpiperidines | LONZA AG (CH) | 2000-06-21 | — | — | EP | claimed |
| US-5789596-A | NEUROKININ RECEPTOR ANTAGONIST | LONZA AG (CH) | 1998-08-04 | — | — | US | claimed |
| EP-0831087-A1 | Process for the preparation of 1-acyl-4-arylpiperidines | LONZA AG (CH) | 1998-03-25 | — | — | EP | claimed |
| JP-10114743-A | — | — | None | — | — | JP | disclosed |
| EP-0831087-B1 | Process for the preparation of 1-acyl-4-arylpiperidines | LONZA AG (CH) | 2000-06-21 | — | — | EP | disclosed |
| US-5908935-A | Process for the preparation of 1-Acyl-4-arylpiperidines | LONZA AG (CH) | 1999-06-01 | — | — | US | disclosed |
| US-5908935-A | Process for the preparation of 1-Acyl-4-arylpiperidines | LONZA AG (CH) | 1999-06-01 | — | — | US | disclosed |
| US-5789596-A | NEUROKININ RECEPTOR ANTAGONIST | LONZA AG (CH) | 1998-08-04 | — | — | US | disclosed |
| US-5789596-A | NEUROKININ RECEPTOR ANTAGONIST | LONZA AG (CH) | 1998-08-04 | — | — | US | disclosed |
| JP-H10114743-A | PRODUCTION OF 1-ACYL-4-ARYLPIPERIDINE | LONZA AG | 1998-05-06 | — | — | JP | disclosed |
| EP-0831087-A1 | Process for the preparation of 1-acyl-4-arylpiperidines | LONZA AG (CH) | 1998-03-25 | — | — | EP | disclosed |
| EP-0831087-A1 | Process for the preparation of 1-acyl-4-arylpiperidines | LONZA AG (CH) | 1998-03-25 | — | — | EP | disclosed |