Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | AOC2 | O75106 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8026173 | 0.84 | HRH3 (0.42) | HRH3HTR1AHTR1DGPBAR1CA2 | |
| SCHEMBL1485141 | 0.83 | HRH3 (0.49) | HRH3HTR2AHRH1HTR1AHTR1D | |
| SCHEMBL1485140 | 0.83 | HRH3 (0.49) | HRH3HTR2AHRH1HTR1AHTR1D | |
| SCHEMBL13638405 | 0.81 | HRH3 (0.47) | HRH3HTR2AHTR1AHTR1DGPBAR1 | |
| SCHEMBL10366459 | 0.78 | HRH3 (0.44) | HRH3HTR1AHTR1DPOLBESR2 | |
| SCHEMBL8036527 | 0.78 | HTR2A (0.41) | HTR2AHRH1SIGMAR1L3MBTL4L3MBTL1 | |
| SCHEMBL8035976 | 0.77 | HRH3 (0.47) | HRH3HTR2AHRH1HTR1AHTR1D | |
| SCHEMBL8026169 | 0.77 | HRH3 (0.47) | HRH3HTR2AHRH1HTR1AHTR1D | |
| SCHEMBL17193871 | 0.77 | HRH3 (0.47) | HRH3SIGMAR1HTR1AHTR1DCA2 | |
| SCHEMBL11535632 | 0.77 | HRH3 (0.47) | HRH3SIGMAR1AOC2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000076990-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | claimed |
| WO-2000076990-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |