SCHEMBL8035976

SCHEMBL8035976

NCC[C@@H]1Cc2ccccc2O1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.47
AOC2 O75106 5/20 0.46
MAOA P21397 5/20 0.46
MAOB P27338 5/20 0.46
DAO P14920 1/20 0.46
HTR2A P28223 1/20 0.42
HRH1 P35367 1/20 0.42
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41
CA2 P00918 2/20 0.41
NISCH Q9Y2I1 1/20 0.38
HTR1A P08908 1/20 0.37
HTR1D P28221 1/20 0.37
CHRM2 P08172 1/20 0.36
CHRM4 P08173 1/20 0.36
CHRM5 P08912 1/20 0.36
CHRM1 P11229 1/20 0.36
CHRM3 P20309 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8026169 1.00 HRH3 (0.47) HRH3AOC2MAOAMAOBDAO
SCHEMBL8038140 1.00 HRH3 (0.47) HRH3AOC2MAOAMAOBDAO
SCHEMBL7797530 0.86 HRH3 (0.43) HRH3AOC2MAOAMAOBDAO
SCHEMBL29841223 0.85 HRH3 (0.49) HRH3AOC2MAOAMAOBDAO
SCHEMBL718265 0.85 HRH3 (0.49) HRH3AOC2MAOAMAOBDAO
Hydrochloric Acid SCHEMBL15825664 0.83 AOC2 (0.51) HRH3AOC2MAOAMAOBDAO
SCHEMBL407503 0.82 CA2 (0.56) SLC6A2SLC6A4SLC6A3CA2HTR1A
SCHEMBL17193871 0.81 HRH3 (0.47) HRH3AOC2MAOAMAOBDAO
SCHEMBL11535632 0.81 HRH3 (0.47) HRH3AOC2MAOAMAOBDAO
SCHEMBL11200558 0.81 HRH3 (0.50) HRH3AOC2MAOAMAOBDAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000076990-A1 NEW COMPOUNDS ASTRAZENECA AB (SE) 2000-12-21 WO disclosed