SCHEMBL8037837

SCHEMBL8037837

C=C1c2ccc3cc(OC)ccc3c2CCN1C(C)=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.50
NOTUM Q6P988 2/20 0.48
TP53 P04637 2/20 0.43
CYP1A2 P05177 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
ALDH1A1 P00352 2/20 0.43
HPGD P15428 1/20 0.43
HSD17B10 Q99714 1/20 0.43
KDM4E B2RXH2 3/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
MAPT P10636 2/20 0.39
LMNA P02545 1/20 0.39
CYP3A4 P08684 1/20 0.39
MAOA P21397 1/20 0.39
SLC6A2 P23975 1/20 0.39
SLC6A3 Q01959 1/20 0.39
BAZ2B Q9UIF8 1/20 0.38
PTGS1 P23219 1/20 0.37
AKR1C3 P42330 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7333499 0.92 NOTUM (0.49) HSP90AA1NOTUMTP53CYP1A2SMN1; SMN2
SCHEMBL7850892 0.75 CYP1A2 (0.53) NOTUMTP53CYP1A2SMN1; SMN2ALDH1A1
SCHEMBL8025914 0.73 HSD17B10 (0.57) NOTUMTP53ALDH1A1HSD17B10KDM4E
SCHEMBL4743709 0.73 BAZ2B (0.56) NOTUMTP53CYP1A2SMN1; SMN2ALDH1A1
SCHEMBL7843326 0.73 NOTUM (0.47) NOTUMSMN1; SMN2ALDH1A1HPGDHSD17B10
SCHEMBL30994678 0.71 HSP90AA1 (0.59) HSP90AA1TP53CYP1A2SMN1; SMN2ALDH1A1
SCHEMBL642522 0.68 NOTUM (0.63) NOTUMSMN1; SMN2ALDH1A1HSD17B10KDM4E
SCHEMBL12111806 0.68 HSP90AA1 (0.60) HSP90AA1TP53CYP1A2SMN1; SMN2ALDH1A1
SCHEMBL17591343 0.67 NOTUM (0.63) NOTUMALDH1A1TRIM24
SCHEMBL11843315 0.67 HSP90AA1 (1.00) HSP90AA1TP53CYP1A2SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6048868-A CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS; ANTIDEPRESSANTS CEMAF (FR) 2000-04-11 US disclosed
EP-0781281-A1 NOVEL MELATONIN AGONIST $g(b)-CARBOLINE DERIVATIVES AND ANALOGS WITH A NAPHTHALENIC STRUCTURE, METHOD FOR THEIR PREPARATION AND THEIR USE AS DRUGS CEMAF (FR) 1997-07-02 EP disclosed
WO-1996008490-A1 NOVEL MELATONIN AGONIST β-CARBOLINE DERIVATIVES AND ANALOGS WITH A NAPHTHALENIC STRUCTURE, METHOD FOR THEIR PREPARATION AND THEIR USE AS DRUGS CEMAF (FR) 1996-03-21 WO disclosed