SCHEMBL7843326

SCHEMBL7843326

C=C1c2c(c3cc(OC)ccc3n2C)CCN1C(C)=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.47
HSD17B10 Q99714 3/20 0.47
DRD2 P14416 1/20 0.45
DRD1 P21728 1/20 0.45
DRD5 P21918 1/20 0.45
DRD3 P35462 1/20 0.45
MAOA P21397 3/20 0.43
ACHE P22303 2/20 0.43
MTNR1A P48039 1/20 0.42
AKR1B10 O60218 1/20 0.42
AKR1A1 P14550 1/20 0.42
AKR1B1 P15121 1/20 0.42
KDM4E B2RXH2 2/20 0.42
MAPT P10636 3/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
NPSR1 Q6W5P4 1/20 0.40
BAZ2B Q9UIF8 1/20 0.40
ALDH1A1 P00352 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8025914 0.88 HSD17B10 (0.57) NOTUMHSD17B10DRD2DRD1DRD5
SCHEMBL7333499 0.76 NOTUM (0.49) NOTUMMAOAMTNR1AKDM4EMAPT
SCHEMBL4743709 0.74 BAZ2B (0.56) NOTUMHSD17B10DRD2MTNR1AKDM4E
SCHEMBL8037837 0.73 HSP90AA1 (0.50) NOTUMHSD17B10MAOAMTNR1AKDM4E
SCHEMBL8036147 0.72 DRD2 (0.47) HSD17B10DRD2DRD1DRD5DRD3
SCHEMBL7850892 0.72 CYP1A2 (0.53) NOTUMHSD17B10MAOAACHEMTNR1A
SCHEMBL8025896 0.69 DRD2 (0.44) HSD17B10DRD2DRD1DRD5DRD3
SCHEMBL4699104 0.68 KDM4E (0.47) HSD17B10DRD2DRD1DRD5DRD3
SCHEMBL14345729 0.68 DRD2 (0.43) HSD17B10DRD2DRD1DRD5DRD3
SCHEMBL8035810 0.68 KDR (0.57) HSD17B10DRD2MTNR1AKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0781281-B1 BETA-CARBOLINE DERIVATIVES AS MELATONIN AGONISTS, METHODS FOR THEIR PREPARATION AND THEIR USE AS DRUGS MACEF (FR) 2001-12-19 EP claimed
EP-0781281-B1 BETA-CARBOLINE DERIVATIVES AS MELATONIN AGONISTS, METHODS FOR THEIR PREPARATION AND THEIR USE AS DRUGS MACEF (FR) 2001-12-19 EP disclosed
US-6048868-A CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS; ANTIDEPRESSANTS CEMAF (FR) 2000-04-11 US disclosed
EP-0781281-A1 NOVEL MELATONIN AGONIST $g(b)-CARBOLINE DERIVATIVES AND ANALOGS WITH A NAPHTHALENIC STRUCTURE, METHOD FOR THEIR PREPARATION AND THEIR USE AS DRUGS CEMAF (FR) 1997-07-02 EP disclosed
WO-1996008490-A1 NOVEL MELATONIN AGONIST β-CARBOLINE DERIVATIVES AND ANALOGS WITH A NAPHTHALENIC STRUCTURE, METHOD FOR THEIR PREPARATION AND THEIR USE AS DRUGS CEMAF (FR) 1996-03-21 WO disclosed