Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TGM2 | P21980 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KYNU | Q16719 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050960 | 0.94 | HTT (0.52) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL8049635 | 0.93 | LMNA (0.57) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL8055648 | 0.88 | HTT (0.53) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL3726894 | 0.88 | HTT (0.60) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL9193616 | 0.84 | HTT (0.48) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL7670412 | 0.84 | HTT (0.53) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL9849581 | 0.83 | HTT (0.47) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL8050193 | 0.82 | HTT (0.54) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL8050092 | 0.81 | LMNA (0.55) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL9190230 | 0.81 | HTT (0.48) | HTTLMNASMN1; SMN2TGM2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563096-B1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 2000-05-03 | — | — | EP | disclosed |
| US-5438048-A | Used for treatment of disorders related to metabolism of calcium and other bivalent metals; treats bone cancer, urolithiasis, rheumatoid arthritis, bone infection and bone degradation | LEIRAS OY (FI) | 1995-08-01 | — | — | US | disclosed |
| EP-0563096-A1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 1993-10-06 | — | — | EP | disclosed |
| WO-1992011267-A1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 1992-07-09 | — | — | WO | disclosed |