SCHEMBL8038746

SCHEMBL8038746

CC[CH]c1cccc(N)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 6/20 0.54
MAOA P21397 4/20 0.54
MAOB P27338 3/20 0.54
CYP3A4 P08684 3/20 0.48
CASP1 P29466 1/20 0.48
RECQL P46063 1/20 0.48
NPC1 O15118 1/20 0.47
MAPT P10636 1/20 0.47
GFER P55789 1/20 0.47
NPSR1 Q6W5P4 1/20 0.46
TP53 P04637 1/20 0.45
ALDH1A1 P00352 3/20 0.40
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA7 P43166 1/20 0.39
CA9 Q16790 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
CA14 Q9ULX7 1/20 0.39
TSHR P16473 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8418939 0.87 CYP19A1 (0.50) CYP19A1MAOAMAOBCYP3A4CASP1
SCHEMBL5329182 0.84 CYP19A1 (0.47) CYP19A1MAOAMAOBCYP3A4CASP1
SCHEMBL2187122 0.83 ALDH1A1 (0.37) MAOAMAOBNPC1TP53ALDH1A1
SCHEMBL16167423 0.81 CYP19A1 (0.59) CYP19A1MAOAMAOBCYP3A4CASP1
SCHEMBL7546214 0.81 CYP19A1 (0.59) CYP19A1MAOAMAOBCYP3A4CASP1
SCHEMBL27258312 0.80 CYP19A1 (0.52) CYP19A1MAOAMAOBCYP3A4CASP1
SCHEMBL27848544 0.78 CYP19A1 (0.50) CYP19A1MAOAMAOBCYP3A4CASP1
SCHEMBL8670587 0.77 CYP19A1 (0.48) CYP19A1MAOAMAOBCYP3A4CASP1
SCHEMBL5592348 0.76
SCHEMBL245731 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000079312-A1 HIGH REFRACTIVE INDEX COMPOSITIONS FOR OPHTHALMIC IMPLANTS BAUSCH & LOMB SURGICAL, INC. (US) 2000-12-28 WO claimed
US-5686486-A 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl b!pyran-2-ones useful to treat retroviral infections PHARMACIA & UPJOHN COMPANY (US) 1997-11-11 US disclosed