Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7386449 | 0.98 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL8049526 | 0.85 | KDM4E (0.42) | ALDH1A1KDM4ENAMPTHTTNPC1 | |
| SCHEMBL7360053 | 0.85 | CFTR (0.49) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL6162613 | 0.84 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL7384705 | 0.83 | BUB1 (0.43) | ALDH1A1KDM4ENAMPTHTTKCNMA1 | |
| SCHEMBL4897236 | 0.83 | CFTR (0.49) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL6770247 | 0.82 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL6303008 | 0.81 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL6770578 | 0.81 | BUB1 (0.50) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL6092190 | 0.81 | BUB1 (0.47) | ALDH1A1MEN1KMT2AKDM4ENAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096887-A | USEFUL IN THE DIAGNOSIS AND TREATMENT OF ANXIETY, SLEEP AND SEIZURE DISORDERS, OVERDOSE WITH BENZODIAZEPINE DRUGS AND FOR ENHANCEMENT OF MEMORY. | NEUROGEN CORPORATION (US) | 2000-08-01 | — | — | US | claimed |
| US-6096887-A | USEFUL IN THE DIAGNOSIS AND TREATMENT OF ANXIETY, SLEEP AND SEIZURE DISORDERS, OVERDOSE WITH BENZODIAZEPINE DRUGS AND FOR ENHANCEMENT OF MEMORY. | NEUROGEN CORPORATION (US) | 2000-08-01 | — | — | US | disclosed |
| WO-1998002433-A1 | CERTAIN FUSED PYRROLECARBOXAMIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1998-01-22 | — | — | WO | disclosed |