Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.56 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.50 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | ARG2 | P78540 | 4/20 | 0.41 |
| ▸ | ARG1 | P05089 | 3/20 | 0.41 |
| ▸ | KIF11 | P52732 | 4/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8039288 | 1.00 | GSR (0.56) | GSRTRIM24TRIM33POLBKMT2A | |
| Lysine SCHEMBL28249818 | 0.87 | GSR (0.69) | GSRPOLBKMT2ATDP1DPP8 | |
| Lysine SCHEMBL28249816 | 0.87 | GSR (0.69) | GSRPOLBKMT2ATDP1DPP8 | |
| Salicyladehyde SCHEMBL8035802 | 0.84 | TRIM24 (0.58) | TRIM24TRIM33KMT2ATDP1KIF11 | |
| Salicyladehyde SCHEMBL8035808 | 0.84 | TRIM24 (0.58) | TRIM24TRIM33KMT2ATDP1KIF11 | |
| 2-Methoxybenzaldehyde SCHEMBL8039080 | 0.82 | GRIK1 (0.51) | GSRPOLBKMT2ATDP1DPP8 | |
| 2-Methoxybenzaldehyde SCHEMBL8039077 | 0.82 | GRIK1 (0.51) | GSRPOLBKMT2ATDP1DPP8 | |
| Lysine SCHEMBL9643349 | 0.81 | GSR (0.61) | GSRPOLBKMT2ATDP1DPP8 | |
| Lysine SCHEMBL1649467 | 0.80 | GSR (0.59) | GSRPOLBKMT2ATDP1DPP8 | |
| Lysine SCHEMBL1650193 | 0.80 | GSR (0.59) | GSRPOLBKMT2ATDP1DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |
| US-3957760-A | AMINO ACID DERIVATIVES | E. R. SQUIBB & SONS, INC. (US) | 1976-05-18 | — | — | US | disclosed |