Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | CA6 | P23280 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL1650193 | 1.00 | GSR (0.59) | GSRKDM4ECA12ALDH1A1CA1 | |
| Lysine SCHEMBL17965939 | 0.99 | GSR (0.57) | GSRKDM4ECA12ALDH1A1CA1 | |
| Lysine SCHEMBL17965940 | 0.99 | GSR (0.57) | GSRKDM4ECA12ALDH1A1CA1 | |
| Phthalic Acid SCHEMBL19210211 | 0.91 | GSR (0.67) | GSRALDH1A1TDP1POLBKMT2A | |
| Phthalic Acid SCHEMBL19210210 | 0.91 | GSR (0.67) | GSRALDH1A1TDP1POLBKMT2A | |
| Lysine SCHEMBL28249816 | 0.89 | GSR (0.69) | GSRTDP1POLBKMT2ADPP8 | |
| Lysine SCHEMBL28249818 | 0.89 | GSR (0.69) | GSRTDP1POLBKMT2ADPP8 | |
| Aspirin SCHEMBL4094492 | 0.87 | KDM4E (0.53) | GSRKDM4ECA12ALDH1A1CA1 | |
| Lysine SCHEMBL28275800 | 0.85 | GSR (0.59) | GSRTDP1POLBKMT2ADPP8 | |
| Salicylic Acid SCHEMBL28307845 | 0.85 | ALDH1A1 (0.50) | KDM4ECA12ALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115607556-A | Medicine for preventing and treating asthma, chronic obstructive pulmonary disease, allergic diseases, etc | 刘力 | 2023-01-17 | — | — | CN | claimed |
| WO-2013020527-A1 | UTILIZATION OF ALAPTIDE AS TRANSDERMAL PENETRATION MODIFIER IN PHARMACEUTICAL COMPOSITIONS FOR HUMAN AND VETERINARY APPLICATIONS CONTAINING ANTI-INFLAMMATORY DRUGS AND/OR ANTIMICROBIAL CHEMOTHERAPEUTICS | UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES BRNO FACULTY OF PHARMACY (CZ) | 2013-02-14 | — | — | WO | claimed |
| US-4988683-A | Administering lysine acetylsalicylate by mouth for pain and hypothermia | CORBIERE JEROME (FR) | 1991-01-29 | — | — | US | claimed |
| US-20250049674-A1 | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING AT LEAST A MEROCYANINE AND A HYDROTROPE | L'OREAL (FR) | 2025-02-13 | — | — | US | disclosed |
| US-20250025393-A1 | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A MEROCYANINE AND DIPROPYLENE GLYCOL | L'OREAL (FR) | 2025-01-23 | — | — | US | disclosed |
| US-20250009625-A1 | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A MEROCYANINE AND AT LEAST ONE DIOL COMPRISING FROM 4 TO 7 CARBON ATOMS | L'OREAL (FR) | 2025-01-09 | — | — | US | disclosed |
| US-20240423888-A1 | COSMETIC AND/OR DERMATOLOGICAL COMPOSITION COMPRISING AT LEAST ONE MEROCYANINE AND AT LEAST ASCORBIC ACID AND/OR A DERIVATIVE THEREOF | L'OREAL (FR) | 2024-12-26 | — | — | US | disclosed |
| CN-118871078-A | Cosmetic or dermatological composition comprising at least a merocyanine and a hydrotrope | 欧莱雅 | 2024-10-29 | — | — | CN | disclosed |
| EP-4447895-A1 | COSMETIC AND/OR DERMATOLOGICAL COMPOSITION COMPRISING AT LEAST ONE MEROCYANINE AND AT LEAST ASCORBIC ACID AND/OR A DERIVATIVE THEREOF | L'OREAL (FR) | 2024-10-23 | — | — | EP | disclosed |
| CN-118804735-A | Cosmetic and/or dermatological composition comprising at least one merocyanine and at least ascorbic acid and/or derivatives thereof | 莱雅公司 | 2024-10-18 | — | — | CN | disclosed |
| CN-118678942-A | Cosmetic or dermatological composition comprising a merocyanine and at least one glycol comprising 4 to 7 carbon atoms | 莱雅公司 | 2024-09-20 | — | — | CN | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| CN-1468104-A | Use of a combination of purine activity and AINS activity for the preparation of an antithrombotic or antiinflammatory agent | ����ŵ÷�¹�˾ | 2004-01-14 | — | — | CN | disclosed |
| EP-0936899-A4 | COSMETIC COMPOSITIONS | PROCTER & GAMBLE (US) | 2002-01-02 | — | — | EP | disclosed |
| US-6267978-B1 | COSMETIC FOR REGULATION OF THE OILY AND/OR SHINY APPEARANCE OF SKIN | THE PROCTER & GAMBLE COMPANY | 2001-07-31 | — | — | US | disclosed |
| US-6143310-A | WATER IN OIL EMULSION CONTAINING AMINO ACID SALT OF SALICYLIC ACID | THE PROCTER & GAMBLE COMPANY (US) | 2000-11-07 | — | — | US | disclosed |
| EP-0936899-A1 | COSMETIC COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998010741-A1 | COSMETIC COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1998-03-19 | — | — | WO | disclosed |
| WO-1996024331-A1 | NEW MEDICAL FORMS WITH PROLONGED EFFECT APPLIED IN EYE MEDICINE AND THE METHOD FOR PREPARATION THEREOF | ÚSTAV MAKROMOLEKULÁRNÍ CHEMIE AKADEMIE VE^¿D C^¿ESKÉ REPUBLIKY (CZ) | 1996-08-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250009625-A1 | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A MEROCYANINE AND AT LEAST ONE DIOL COMPRISING FROM 4 TO 7 CARBON ATOMS | KRT18, DSC1, ECH1 | GSR 3097/4885KDM4E 2121/4885CA12 141/4885 |
| US-20240423888-A1 | COSMETIC AND/OR DERMATOLOGICAL COMPOSITION COMPRISING AT LEAST ONE MEROCYANINE AND AT LEAST ASCORBIC ACID AND/OR A DERIVATIVE THEREOF | KRT18, PROC, DSC1 | GSR 1290/4885KDM4E 1082/4885CA12 547/4885 |
| US-20250049674-A1 | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING AT LEAST A MEROCYANINE AND A HYDROTROPE | NAPRT, NAMPT, NNMT | GSR 2121/4885KDM4E 2686/4885CA12 961/4885 |
| US-20250025393-A1 | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A MEROCYANINE AND DIPROPYLENE GLYCOL | KRT18, DSC1, DSG1 | GSR 3344/4885KDM4E 1786/4885CA12 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.