Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3422889 | 0.75 | ROCK1 (0.49) | ROCK1L3MBTL1JAK2JAK3PTK2 | |
| SCHEMBL3145069 | 0.72 | ROCK1 (0.46) | ROCK1L3MBTL1JAK2JAK3PTK2 | |
| SCHEMBL11199183 | 0.70 | ROCK1 (0.43) | ROCK1L3MBTL1JAK2JAK3PTK2 | |
| SCHEMBL4431357 | 0.69 | ROCK1 (0.56) | ROCK1L3MBTL1JAK2JAK3PTK2 | |
| SCHEMBL29478502 | 0.69 | ROCK1 (0.51) | ROCK1L3MBTL1JAK2JAK3PTK2 | |
| SCHEMBL693233 | 0.69 | ROCK1 (0.51) | ROCK1L3MBTL1JAK2JAK3PTK2 | |
| SCHEMBL5245431 | 0.68 | ROCK1 (0.63) | ROCK1L3MBTL1JAK2JAK3PTK2 | |
| SCHEMBL17486069 | 0.68 | JAK2 (0.53) | ROCK1L3MBTL1JAK2JAK3PTK2 | |
| SCHEMBL11880068 | 0.67 | ROCK1 (0.50) | ROCK1L3MBTL1JAK2JAK3PTK2 | |
| SCHEMBL10621398 | 0.67 | ROCK1 (0.54) | ROCK1L3MBTL1JAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000066562-A1 | PYRAZOLES HAVING ANTIINFLAMMATORY ACTIVITY | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2000-11-09 | — | — | WO | claimed |
| WO-2000066562-A1 | PYRAZOLES HAVING ANTIINFLAMMATORY ACTIVITY | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2000-11-09 | — | — | WO | disclosed |