Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3145069 | 0.76 | ROCK1 (0.46) | ROCK1L3MBTL1JAK2JAK3PTK2 | |
| SCHEMBL15414802 | 0.76 | ALDH1A1 (0.39) | L3MBTL1HSD17B10KMT2AALDH1A1MEN1 | |
| SCHEMBL8039359 | 0.75 | ROCK1 (0.45) | ROCK1L3MBTL1JAK2JAK3PTK2 | |
| SCHEMBL5245431 | 0.72 | ROCK1 (0.63) | ROCK1L3MBTL1JAK2JAK3PTK2 | |
| SCHEMBL15539900 | 0.72 | PIM1 (0.37) | L3MBTL1HSD17B10ALDH1A1MAPT | |
| SCHEMBL3765155 | 0.72 | NUDT1 (0.46) | PTK2NUDT1SMN1; SMN2POLBKMT2A | |
| SCHEMBL28506498 | 0.71 | ROCK1 (0.54) | ROCK1L3MBTL1JAK2JAK3PTK2 | |
| SCHEMBL11199183 | 0.71 | ROCK1 (0.43) | ROCK1L3MBTL1JAK2JAK3PTK2 | |
| SCHEMBL18012073 | 0.70 | ROCK1 (0.64) | ROCK1L3MBTL1JAK2JAK3PTK2 | |
| SCHEMBL21788620 | 0.70 | ROCK1 (0.56) | ROCK1L3MBTL1JAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9782407-B2 | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2017-10-10 | — | — | US | disclosed |
| EP-1848430-B1 | NOVEL BENZYLAMINE DERIVATIVES AS CETP INHIBITORS | Dr Reddys Laboratories Ltd (IN) | 2017-08-02 | — | — | EP | disclosed |
| US-20170071930-A1 | PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS | DR. REDDY'S LABORATORIES, LTD. (IN) | 2017-03-16 | — | — | US | disclosed |
| US-20160000799-A1 | PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS | DR. REDDY'S LABORATORIES, LTD. (IN) | 2016-01-07 | — | — | US | disclosed |
| CN-103102303-B | As the benzyl amine derivative of CETP inhibitor | DR. REDDY'S LABORATORIES LTD. (IN) | 2015-10-28 | — | — | CN | disclosed |
| EP-2919765-A2 | PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS | Dr. Reddy's Laboratories Ltd. (IN) | 2015-09-23 | — | — | EP | disclosed |
| US-20150216866-A1 | SUBSTITUTED BENZYLAMINO QUINOLINES AS CHOLESTEROL ESTER-TRANSFER PROTEIN INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2015-08-06 | — | — | US | disclosed |
| US-9040558-B2 | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2015-05-26 | — | — | US | disclosed |
| US-20140243282-A1 | METHODS AND COMPOSITIONS FOR DESIGNING NOVEL CONJUGATE THERAPEUTICS | KALLAM SATISH REDDY (US) | 2014-08-28 | — | — | US | disclosed |
| WO-2014128564-A2 | PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2014-08-28 | — | — | WO | disclosed |
| US-20140134235-A1 | NOVEL BENZYLAMINE DERIVATIVES AND THEIR UTILITY AS CHOLESTEROL ESTER-TRANSFER PROTEIN INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2014-05-15 | — | — | US | disclosed |
| US-8604055-B2 | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2013-12-10 | — | — | US | disclosed |
| WO-2012090104-A1 | METHODS AND COMPOSITIONS FOR DESIGNING NOVEL CONJUGATE THERAPEUTICS | KAREUS THERAPEUTICS, SA (CH) | 2012-07-05 | — | — | WO | disclosed |
| US-7700774-B2 | Heterocyclic compounds and their pharmaceutical compositions | DR. REDDY'S LABORATORIES LTD. (IN) | 2010-04-20 | — | — | US | disclosed |
| EP-1848430-A2 | NOVEL BENZYLAMINE DERIVATIVES AS CETP INHIBITORS | Reddy US Therapeutics, Inc. (US) | 2007-10-31 | — | — | EP | disclosed |
| US-20070015758-A1 | Novel benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-01-18 | — | — | US | disclosed |
| US-20060178514-A1 | Novel benzylamine derivatives as CETP inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2006-08-10 | — | — | US | disclosed |
| WO-2006073973-A2 | NOVEL BENZYLAMINE DERIVATIVES AS CETP INHIBITORS | REDDY US THERAPEUTICS, INC. (US) | 2006-07-13 | — | — | WO | disclosed |
| WO-2006069162-A1 | NOVEL HETEROCYCLIC COMPOUNDS AND THEIR PHARMACEUTICAL COMPOSITIONS | REDDY US THERAPEUTICS, INC. (US) | 2006-06-29 | — | — | WO | disclosed |
| US-20060135551-A1 | Novel heterocyclic compounds and their pharmaceutical compositions | DR. REDDY'S LABORATORIES LTD. (IN) | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140134235-A1 | NOVEL BENZYLAMINE DERIVATIVES AND THEIR UTILITY AS CHOLESTEROL ESTER-TRANSFER PROTEIN INHIBITORS | CETP, NPC1, DBI | ROCK1 2580/4885L3MBTL1 363/4885JAK2 4645/4885 |
| US-20150216866-A1 | SUBSTITUTED BENZYLAMINO QUINOLINES AS CHOLESTEROL ESTER-TRANSFER PROTEIN INHIBITORS | CETP, NPC1, MTTP | ROCK1 3353/4885L3MBTL1 394/4885JAK2 4831/4885 |
| US-20160000799-A1 | PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS | CETP, LCAT, MTTP | ROCK1 4092/4885L3MBTL1 3939/4885JAK2 4884/4885 |
| US-20070015758-A1 | Novel benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors | CETP, NPC1, DBI | ROCK1 2580/4885L3MBTL1 363/4885JAK2 4645/4885 |
| US-20170071930-A1 | PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS | CETP, NPC1, CES1 | ROCK1 2359/4885L3MBTL1 4769/4885JAK2 4880/4885 |
| US-20060178514-A1 | Novel benzylamine derivatives as CETP inhibitors | CETP, NPC1, LIPC | ROCK1 3476/4885L3MBTL1 659/4885JAK2 4529/4885 |
| US-20060135551-A1 | Novel heterocyclic compounds and their pharmaceutical compositions | LIPC, PCSK9, PC | ROCK1 3812/4885L3MBTL1 4488/4885JAK2 2589/4885 |
| US-20140243282-A1 | METHODS AND COMPOSITIONS FOR DESIGNING NOVEL CONJUGATE THERAPEUTICS | EPHA2, C3AR1, FCGRT | ROCK1 716/4885L3MBTL1 2896/4885JAK2 1741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.