Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 4/20 | 0.51 |
| ▸ | CTSH | P09668 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8040086 | 0.81 | KDM4E (0.45) | CTSBCTSHMAPTMEN1KMT2A | |
| SCHEMBL22439175 | 0.74 | NQO2 (0.43) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL30076339 | 0.73 | MAPT (0.49) | CTSBCTSHMAPTMEN1KMT2A | |
| SCHEMBL28991131 | 0.73 | MAPT (0.49) | CTSBCTSHMAPTMEN1KMT2A | |
| SCHEMBL8040099 | 0.73 | SMN1; SMN2 (0.43) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL15880740 | 0.72 | TDP1 (0.48) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL27632064 | 0.71 | SMN1; SMN2 (0.45) | CTSBCTSHMAPTMEN1KMT2A | |
| SCHEMBL21681205 | 0.70 | HTT (0.44) | CTSBCTSHMAPTMEN1KMT2A | |
| SCHEMBL10551923 | 0.69 | MEN1 (0.62) | MAPTMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL31444804 | 0.68 | MAPT (0.56) | CTSBCTSHMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130217-A | ANTITUMOR | PFIZER INC (US) | 2000-10-10 | — | — | US | disclosed |
| WO-1994022846-A1 | COMPOUNDS ENHANCING ANTITUMOR ACTIVITY OF OTHER CYTOTOXIC AGENTS | PFIZER INC. (US) | 1994-10-13 | — | — | WO | disclosed |