Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13885581 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL20597519 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL22439175 | 0.79 | NQO2 (0.43) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL8057785 | 0.76 | ALDH1A1 (0.56) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL12584953 | 0.73 | MEN1 (0.51) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL8040184 | 0.73 | CTSB (0.51) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL21091526 | 0.72 | NQO2 (0.43) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL30601538 | 0.72 | NQO2 (0.43) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL30189756 | 0.70 | ALDH1A1 (0.44) | MAPTMEN1KMT2ALMNAPOLB | |
| SCHEMBL19783365 | 0.70 | ALDH1A1 (0.44) | MAPTMEN1KMT2ALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130217-A | ANTITUMOR | PFIZER INC (US) | 2000-10-10 | — | — | US | disclosed |
| WO-1994022846-A1 | COMPOUNDS ENHANCING ANTITUMOR ACTIVITY OF OTHER CYTOTOXIC AGENTS | PFIZER INC. (US) | 1994-10-13 | — | — | WO | disclosed |