Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 11/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214171 | 0.88 | PTGS2 (0.52) | PTGS2PTGS1 | |
| SCHEMBL8040605 | 0.88 | PTGS2 (0.54) | PTGS2PTGS1MAOAMAOBKIF11 | |
| SCHEMBL8040674 | 0.85 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL8053210 | 0.80 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL8051564 | 0.79 | PTGS2 (0.44) | PTGS2PTGS1 | |
| SCHEMBL8040698 | 0.78 | PTGS2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL8051577 | 0.77 | PTGS2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL8053441 | 0.77 | PTGS2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL28750579 | 0.77 | ENPP1 (0.41) | PTGS2PTGS1 | |
| SCHEMBL8055349 | 0.76 | PTGS2 (0.41) | PTGS2PTGS1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808305-B1 | 3,4-DIARYL SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-05-03 | — | — | EP | claimed |
| EP-0808305-A1 | 3,4-DIARYL SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | claimed |
| WO-1996024585-A1 | 3,4-DIARYL SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | claimed |
| EP-0808305-B1 | 3,4-DIARYL SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-05-03 | — | — | EP | disclosed |
| EP-0808305-A1 | 3,4-DIARYL SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| US-5596008-A | ANALGESICS, ANTIARTHRITIC | G. D. SEARLE & CO. (US) | 1997-01-21 | — | — | US | disclosed |
| WO-1996024585-A1 | 3,4-DIARYL SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |