Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045963 | 0.87 | MAPK14 (0.58) | RIPK2RAB9ALMNASMN1; SMN2MAPK14 | |
| SCHEMBL8044057 | 0.85 | RIPK2 (0.50) | RIPK2RAB9ALMNASMN1; SMN2MAPK14 | |
| SCHEMBL8040355 | 0.85 | RIPK2 (0.50) | RIPK2RAB9ALMNASMN1; SMN2MAPK14 | |
| SCHEMBL8049817 | 0.85 | RIPK2 (0.50) | RIPK2RAB9ALMNASMN1; SMN2MAPK14 | |
| SCHEMBL8049319 | 0.85 | RIPK2 (0.50) | RIPK2RAB9ALMNASMN1; SMN2MAPK14 | |
| SCHEMBL8041768 | 0.82 | RIPK2 (0.50) | RIPK2RAB9ALMNASMN1; SMN2MAPK14 | |
| SCHEMBL8043562 | 0.82 | RIPK2 (0.50) | RIPK2RAB9ALMNASMN1; SMN2MAPK14 | |
| SCHEMBL31260788 | 0.81 | RAB9A (0.58) | RAB9ALMNASMN1; SMN2NPC1 | |
| SCHEMBL12920984 | 0.79 | RIPK2 (0.44) | RIPK2RAB9ALMNASMN1; SMN2MAPK14 | |
| SCHEMBL3830233 | 0.78 | RIPK2 (0.71) | RIPK2RAB9ALMNASMN1; SMN2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009068617-A1 | 1, 5-DIHYDRO-PYRAZOLO (3, 4-D) PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS FOR THE TEATMENT OF CNS DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-04 | — | — | WO | disclosed |