Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8049019 | 0.89 | RECQL (0.47) | ALDH1A1HPGDHTTRECQLMAPT | |
| SCHEMBL8043982 | 0.89 | ALDH1A1 (0.47) | ALDH1A1HPGDHTTMAPTKMT2A | |
| SCHEMBL8048227 | 0.88 | SMN1; SMN2 (0.48) | ALDH1A1HPGDHTTRECQLMAPT | |
| SCHEMBL8046748 | 0.88 | RECQL (0.39) | ALDH1A1HPGDHTTRECQLMAPT | |
| SCHEMBL8048302 | 0.88 | KMT2A (0.39) | ALDH1A1HPGDHTTRECQLMAPT | |
| SCHEMBL8045202 | 0.87 | ALDH1A1 (0.39) | ALDH1A1HPGDHTTRECQLMAPT | |
| SCHEMBL8047493 | 0.84 | CYP1A2 (0.40) | ALDH1A1HPGDHTTMAPTKMT2A | |
| SCHEMBL8051728 | 0.84 | CA1 (0.44) | — | |
| SCHEMBL8033914 | 0.81 | POLB (0.43) | ALDH1A1HPGDHTTMAPTKMT2A | |
| SCHEMBL8032703 | 0.81 | KMT2A (0.44) | ALDH1A1HPGDHTTMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |