Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.89 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL29587574 | 0.97 | CA4 (0.94) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| Citric Acid SCHEMBL22686437 | 0.97 | CA4 (0.94) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| Citric Acid SCHEMBL42945 | 0.97 | CA4 (0.94) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| Citric Acid SCHEMBL1291555 | 0.97 | CA4 (0.94) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| Citric Acid SCHEMBL1170541 | 0.95 | CA4 (0.80) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| Citric Acid SCHEMBL23012792 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL21555662 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL776318 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL20668544 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL3597964 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0583778-B1 | Packaging material for photographic photosensitive materials and package | FUJI PHOTO FILM CO LTD (JP) | 2000-03-22 | — | — | EP | disclosed |
| EP-0583778-A2 | Packaging material for photographic photosensitive materials and package | FUJI PHOTO FILM CO., LTD. (JP) | 1994-02-23 | — | — | EP | disclosed |
| US-5219554-A | NMR imaging; diagnosis | ADVANCED MAGNETICS, INC. (US) | 1993-06-15 | — | — | US | disclosed |
| US-5069216-A | Silanized biodegradable super paramagnetic metal oxides as contrast agents for imaging the gastrointestinal tract | ADVANCED MAGNETICS INC. (US) | 1991-12-03 | — | — | US | disclosed |
| US-4951675-A | NUCLEAR MAGNETIC RESONANCE | ADVANCED MAGNETICS, INCORPORATED (US) | 1990-08-28 | — | — | US | disclosed |
| US-4827945-A | MAGNETIC RESONANCE IMAGING | ADVANCED MAGNETICS, INCORPORATED (US) | 1989-05-09 | — | — | US | disclosed |