Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.58 |
| ▸ | PDE5A | O76074 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042391 | 0.87 | PDE5A (0.63) | SMN1; SMN2NPSR1ALDH1A1KMT2AHPGD | |
| SCHEMBL8042386 | 0.83 | HIF1A (0.84) | SMN1; SMN2HIF1ALMNA | |
| SCHEMBL1063668 | 0.77 | PDE5A (0.81) | ALDH1A1KMT2APDE5APTGS1TBXAS1 | |
| SCHEMBL13381616 | 0.76 | SMN1; SMN2 (0.73) | SMN1; SMN2NPSR1ALDH1A1KMT2AHPGD | |
| SCHEMBL7442498 | 0.76 | PDE5A (0.77) | ALDH1A1KMT2APDE5APTGS1TBXAS1 | |
| SCHEMBL8042401 | 0.73 | HIF1A (0.85) | SMN1; SMN2HIF1ALMNA | |
| SCHEMBL2583256 | 0.73 | PDE5A (0.90) | ALDH1A1KMT2AHPGDPDE5APTGS1 | |
| SCHEMBL29546979 | 0.72 | HIF1A (1.00) | SMN1; SMN2HIF1ALMNA | |
| SCHEMBL14519422 | 0.72 | MAPK14 (0.54) | NPSR1ALDH1A1KMT2AHPGDPDE5A | |
| SCHEMBL19911080 | 0.72 | HIF1A (1.00) | SMN1; SMN2HIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | claimed |
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |