Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | GBA1 | P04062 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042396 | 0.87 | SMN1; SMN2 (0.59) | PDE5AHIF1AALDH1A1KMT2AMEN1 | |
| SCHEMBL8042386 | 0.81 | HIF1A (0.84) | HIF1ALMNASMN1; SMN2 | |
| SCHEMBL432876 | 0.77 | PDE5A (1.00) | PDE5AHIF1ACLK4ALDH1A1CYP1A2 | |
| SCHEMBL30085696 | 0.76 | CLK4 (0.58) | PDE5AHIF1ACLK4ALDH1A1CYP1A2 | |
| SCHEMBL30085548 | 0.75 | CLK4 (0.60) | PDE5ACLK4ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14262933 | 0.74 | CYP1A2 (0.84) | PDE5AHIF1ACLK4ALDH1A1CYP1A2 | |
| SCHEMBL7286130 | 0.73 | PDE5A (1.00) | PDE5AHIF1ACLK4ALDH1A1CYP1A2 | |
| SCHEMBL13381616 | 0.73 | SMN1; SMN2 (0.73) | HIF1AALDH1A1CYP1A2CYP2C19KMT2A | |
| SCHEMBL29546979 | 0.71 | HIF1A (1.00) | HIF1ALMNASMN1; SMN2 | |
| SCHEMBL19911080 | 0.71 | HIF1A (1.00) | HIF1ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | claimed |
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |