Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.44 |
| ▸ | KMO | O15229 | 7/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12908040 | 1.00 | RORC (0.51) | RORCSYKCSNK2A1KMOGRM2 | |
| SCHEMBL12908041 | 1.00 | RORC (0.51) | RORCSYKCSNK2A1KMOGRM2 | |
| SCHEMBL14294081 | 0.92 | RORC (0.54) | RORCSYKCSNK2A1KMOMAPT | |
| SCHEMBL17708435 | 0.85 | RORC (0.42) | RORCSYKCSNK2A1MAPTRAB9A | |
| SCHEMBL12908030 | 0.85 | CSNK2A1 (0.59) | RORCSYKCSNK2A1KMORAB9A | |
| SCHEMBL13678433 | 0.85 | CSNK2A1 (0.55) | RORCSYKCSNK2A1KMOMAPT | |
| SCHEMBL5369456 | 0.81 | HTR2C (0.51) | RORCSYKCSNK2A1HRH1 | |
| SCHEMBL12908033 | 0.81 | SYK (0.67) | RORCSYKCSNK2A1GRM2P2RX3 | |
| SCHEMBL19139905 | 0.80 | RORC (0.45) | RORCSYKCSNK2A1KMONPSR1 | |
| SCHEMBL8042420 | 0.80 | RORC (0.45) | RORCSYKCSNK2A1KMONPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220083-B1 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2017-07-19 | — | — | EP | disclosed |
| WO-2009062676-A2 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |