Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.53 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.50 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20215892 | 0.90 | ALDH1A1 (0.44) | EPHX2SIGMAR1ALDH1A1EPHX1TAS1R3 | |
| SCHEMBL16853213 | 0.88 | TRPV1 (0.40) | EPHX2SIGMAR1ALDH1A1EPHX1TAS1R3 | |
| SCHEMBL4863536 | 0.81 | EPHX2 (0.59) | EPHX2SIGMAR1ALDH1A1EPHX1TAS1R3 | |
| SCHEMBL5590888 | 0.80 | EPHX2 (0.58) | EPHX2SIGMAR1ALDH1A1EPHX1TAS1R3 | |
| SCHEMBL5590882 | 0.80 | EPHX2 (0.58) | EPHX2SIGMAR1ALDH1A1EPHX1TAS1R3 | |
| SCHEMBL5590880 | 0.80 | EPHX2 (0.58) | EPHX2SIGMAR1ALDH1A1EPHX1TAS1R3 | |
| SCHEMBL19688352 | 0.80 | EPHX2 (0.58) | EPHX2SIGMAR1ALDH1A1EPHX1TAS1R3 | |
| SCHEMBL3071717 | 0.79 | EPHX2 (0.61) | EPHX2SIGMAR1ALDH1A1EPHX1TAS1R3 | |
| SCHEMBL3068813 | 0.79 | EPHX1 (0.76) | EPHX2SIGMAR1ALDH1A1EPHX1TAS1R3 | |
| SCHEMBL3065279 | 0.79 | EPHX2 (0.53) | EPHX2SIGMAR1ALDH1A1EPHX1TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0868420-B1 | 3-PYRAZOLECARBOXAMIDE DERIVATIVES HAVING CANNABINOID RECEPTOR AFFINITY | SANOFI SYNTHELABO (FR) | 2000-03-29 | — | — | EP | disclosed |
| EP-0885889-A2 | Process for the preparation of pyrazole-3-carboxylic acids | SANOFI (FR) | 1998-12-23 | — | — | EP | disclosed |
| US-5624941-A | Pyrazole derivatives, method of preparing them and pharmaceutical compositions in which they are present | SANOFI (FR) | 1997-04-29 | — | — | US | disclosed |
| EP-0576357-B1 | Pyrazole derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1997-03-05 | — | — | EP | disclosed |
| EP-0576357-A1 | Pyrazole derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1993-12-29 | — | — | EP | disclosed |