SCHEMBL8042775

SCHEMBL8042775

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nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25157 1.00
SCHEMBL15972083 0.77 ALDH1A1 (0.32)
SCHEMBL4620404 0.75
SCHEMBL10482863 0.75 ALDH1A1 (0.41)
SCHEMBL3683448 0.75
SCHEMBL11126902 0.73 CES1 (0.40)
SCHEMBL4655211 0.73 TSHR (0.33)
SCHEMBL4642212 0.73 CA1 (0.44)
SCHEMBL9793411 0.72 TSHR (0.44)
SCHEMBL2825581 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103504-A STREPTOMYCES MUTANT LACKING BRANCHED-CHAIN AMINO ACID TRANSAMINASE ACTIVITY, BRANCHED-CHAIN OXO ACID BIOSYNTHETIC ACTIVITY AND LACKING AVERMECTIN B-O-METHYL TRANSFERASE ACTIVITY; FOR PRODUCTION OF PARASITIDES AND ANTHELMINTICS PFIZER INC. (US) 2000-08-15 US disclosed
EP-0640142-B1 PROCESS FOR PRODUCTION OF AVERMECTINS AND CULTURES THEREFOR PFIZER (US) 1998-05-20 EP disclosed
US-5583015-A CULTURING MUTANT STRAIN OF STREPTOMYCES AVERMITILIS LACKING BRANCHED CHAIN AMINO ACID TRANSAMINASE AND/OR 2-OXO ACID DEHYDROGENASE ACTIVITY UNDER AEROBIC CONDITIONS IN AQUEOUS NUTRIENT MEDIUM CONTAINING SPECIFIED ACID OR PRECURSOR PFIZER INC. (US) 1996-12-10 US disclosed
US-5583029-A PARASITICIDES PFIZER INC. (US) 1996-12-10 US disclosed
US-5576199-A CULTURE OF STREPTOMYCES UNDER AEROBIC CONDITIONS IN NUTRIENTS PFIZER INC. (US) 1996-11-19 US disclosed
US-5576200-A CULTURING A MUTANT STRAIN OF STREPTOMYCES PFIZER INC. (US) 1996-11-19 US disclosed
US-5565359-A STREPTOMYCES CULTURED UNDER AEROBIC CONDITIONS IN NUTRIENT MEDIA CONTAINING AN ACID PFIZER INC. (US) 1996-10-15 US disclosed
US-5525506-A Process for production of avermectins and cultures therefor PFIZER INC. (US) 1996-06-11 US disclosed
EP-0640142-A1 PROCESS FOR PRODUCTION OF AVERMECTINS AND CULTURES THEREFOR PFIZER INC. (US) 1995-03-01 EP disclosed
US-5387509-A ANTIPARASITIC AGENTS PFIZER INC. (US) 1995-02-07 US disclosed
US-5234831-A From Streptomyces PFIZER INC (US) 1993-08-10 US disclosed
EP-0313297-B1 PROCESS FOR PRODUCTION OF AVERMECTIN AGLYCONES AND CULTURES THEREFOR PFIZER INC. (US) 1993-05-19 EP disclosed
EP-0316124-B1 ETHYLATED AVERMECTINS PFIZER INC. (US) 1993-04-07 EP disclosed
EP-0276131-B1 NON-NATURAL DEMETHYLAVERMECTINS AND PROCESS THEREFOR PFIZER INC. (US) 1993-04-07 EP disclosed
US-5077278-A Parasiticides PFIZER INC. (US) 1991-12-31 US disclosed
EP-0316124-A2 Ethylated avermectins PFIZER INC. (US) 1989-05-17 EP disclosed
EP-0313297-A2 Process for production of avermectin aglycones and cultures therefor PFIZER INC. (US) 1989-04-26 EP disclosed
EP-0284176-A2 Process for production of avermectins and cultures therefor PFIZER INC. (US) 1988-09-28 EP disclosed
EP-0276103-A2 Process for production of B avermectins and cultures therefor PFIZER INC. (US) 1988-07-27 EP disclosed
EP-0276131-A2 Non-natural demethylavermectins and process therefor PFIZER INC. (US) 1988-07-27 EP disclosed