SCHEMBL8042887

SCHEMBL8042887

N#Cc1cc(CN2CC[C@H](NS(=O)(=O)c3cc4ccc(F)cc4s3)C2=O)ccn1

nearest known ligand 0.52

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.52
PROC P04070 5/20 0.48
PLAT P00750 5/20 0.48
PRSS1 P07477 3/20 0.48
F2 P00734 8/20 0.45
PLG P00747 5/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8040059 0.83 F10 (0.59) F10PROCPLATPRSS1F2
Hydrochloric Acid SCHEMBL8040061 0.83 F10 (0.59) F10PROCPLATPRSS1F2
Hydrochloric Acid SCHEMBL8040971 0.75 F10 (0.59) F10PROCPLATPRSS1F2
SCHEMBL2326339 0.75 F10 (0.74) F10PROCPRSS1F2PLG
SCHEMBL7539268 0.75 F10 (0.63) F10PROCPLATPRSS1F2
SCHEMBL8623632 0.74 F10 (0.56) F10PROCPLATPRSS1F2
SCHEMBL2325700 0.74 F10 (0.65) F10PROCPLATF2PLG
SCHEMBL7422298 0.74 PRMT5 (0.42) F10F2
Trifluoroacetic Acid SCHEMBL7486215 0.73 F10 (0.65) F10PROCPLATPRSS1F2
Trifluoroacetic Acid SCHEMBL7486212 0.73 F10 (0.65) F10PROCPLATPRSS1F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6034093-A Substituted sulfonic acid N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 2000-03-07 US disclosed