SCHEMBL8043188

SCHEMBL8043188

O=[C]C1Cc2ccccc2OO1

nearest known ligand 0.33

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MAOA P21397 6/20 0.33
MAOB P27338 6/20 0.33
CHRM2 P08172 2/20 0.33
CHRM4 P08173 2/20 0.33
CHRM5 P08912 2/20 0.33
CHRM1 P11229 2/20 0.33
CHRM3 P20309 2/20 0.33
HPGD P15428 1/20 0.33
TSHR P16473 1/20 0.33
SIRT1 Q96EB6 1/20 0.33
AOC2 O75106 5/20 0.30
DAO P14920 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2653890 0.81 HPGD (0.41) MAOAMAOBCHRM2CHRM4CHRM5
SCHEMBL449445 0.75 MAOA (0.37) MAOAMAOBCHRM2CHRM4CHRM5
SCHEMBL5572317 0.72 MAOA (0.38) MAOAMAOBCHRM2CHRM4CHRM5
SCHEMBL2449240 0.71 MAOA (0.37) MAOAMAOBCHRM2CHRM4CHRM5
SCHEMBL10654103 0.71 MAOB (0.39) MAOAMAOBCHRM2CHRM4CHRM5
SCHEMBL11381215 0.71 MAOA (0.37) MAOAMAOBCHRM2CHRM4CHRM5
SCHEMBL1890900 0.71 MAOA (0.37) MAOAMAOBAOC2DAO
SCHEMBL2452704 0.70 HRH3 (0.37) MAOAMAOBHPGDTSHRAOC2
SCHEMBL3568565 0.70 MAOA (0.33) MAOAMAOBCHRM2CHRM4CHRM5
SCHEMBL3568561 0.70 HPGD (0.46) MAOAMAOBHPGDTSHRAOC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6080860-A UREA COMPOUND WHERE ONE OF THE UREA NITROGENS IS PART OF AN (UN)SUBSTITUTED 5 OR 6 MEMBERED RING AND/OR THE OTHER UREA NITROGEN IS SUBSTITUTED WITH A 2-CYANO-4,5-DIALKOXYPHENYL GROUP; REACTING WITH ELECTROPHILE TO FORM A LEAVING GROUP BRANTFORD CHEMICALSS INC. (CA) 2000-06-27 US claimed
US-6080860-A UREA COMPOUND WHERE ONE OF THE UREA NITROGENS IS PART OF AN (UN)SUBSTITUTED 5 OR 6 MEMBERED RING AND/OR THE OTHER UREA NITROGEN IS SUBSTITUTED WITH A 2-CYANO-4,5-DIALKOXYPHENYL GROUP; REACTING WITH ELECTROPHILE TO FORM A LEAVING GROUP BRANTFORD CHEMICALSS INC. (CA) 2000-06-27 US disclosed
US-5686612-A ACCELERATORS IN THE MANUFACTURE OF RUBBER AND ACTIVATORS FOR THIAZOLE ACCELERATORS BRANTFORD CHEMICALS INC. (CA) 1997-11-11 US disclosed
US-5675006-A REACTING INTERMEDIATE WITH PIPERAZINE OR 1,4-DIAZAPINE DERIVATIVES OR AMMONIA TO FORM CHEMICAL INTERMEDIATE, CLOSING THE RING BRANTFORD CHEMICALS INC. (CA) 1997-10-07 US disclosed
EP-0656885-A1 SYNTHESIS OF 2-SUBSTITUTED QUINAZOLINE COMPOUNDS (SUCH AS TERAZOSIN) AND MEOBENTINE AND BETHANIDINE AND INTERMEDIATES THEREFOR ACIC (CANADA) INC. (CA) 1995-06-14 EP disclosed
WO-1994005628-A1 SYNTHESIS OF 2-SUBSTITUTED QUINAZOLINE COMPOUNDS (SUCH AS TERAZOSIN) AND MEOBENTINE AND BETHANIDINE AND INTERMEDIATES THEREFOR ACIC (CANADA) INC. (CA) 1994-03-17 WO disclosed
US-4472300-A ANTIMICROBIAL FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1984-09-18 US disclosed
US-4207234-A 4-Unsubstituted azetidinone derivatives and process for preparation thereof FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1980-06-10 US disclosed