Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 8/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.49 |
| ▸ | ACP1 | P24666 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045572 | 0.85 | HIF1A (0.80) | HIF1AKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL8043618 | 0.80 | SMN1; SMN2 (0.51) | HIF1AKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL8049564 | 0.79 | HIF1A (0.81) | HIF1A | |
| SCHEMBL8041613 | 0.78 | HIF1A (0.60) | HIF1AKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL8032085 | 0.78 | HIF1A (0.52) | HIF1AHTTSMN1; SMN2AHRNPC1 | |
| SCHEMBL8043537 | 0.76 | HIF1A (0.77) | HIF1AKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL8041622 | 0.75 | HIF1A (0.58) | HIF1AKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL8032069 | 0.75 | HIF1A (0.77) | HIF1AKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL8032094 | 0.75 | HIF1A (0.92) | HIF1AKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL8042397 | 0.75 | HIF1A (0.79) | HIF1AKDM4ELMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | claimed |
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |