Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043544 | 0.88 | HIF1A (0.46) | SMN1; SMN2KMT2APPP1CAHIF1AKDM4E | |
| SCHEMBL8041599 | 0.84 | HIF1A (0.48) | SMN1; SMN2HIF1AKDM4ELMNAHTT | |
| SCHEMBL8043500 | 0.80 | HIF1A (0.57) | SMN1; SMN2NPC1RAB9AHIF1AKDM4E | |
| SCHEMBL8032107 | 0.78 | HIF1A (0.45) | SMN1; SMN2HIF1AKDM4ELMNAHTT | |
| SCHEMBL8041613 | 0.77 | HIF1A (0.60) | SMN1; SMN2HIF1AKDM4ELMNAHTT | |
| SCHEMBL8032085 | 0.77 | HIF1A (0.52) | SMN1; SMN2NPC1RAB9AKMT2APPP1CA | |
| SCHEMBL8045572 | 0.77 | HIF1A (0.80) | SMN1; SMN2HIF1AKDM4ELMNAHTT | |
| SCHEMBL21814279 | 0.77 | TP53 (0.60) | SMN1; SMN2NPC1RAB9AHIF1AKDM4E | |
| SCHEMBL8043595 | 0.76 | GRM5 (0.51) | SMN1; SMN2NPC1RAB9AKMT2AHIF1A | |
| SCHEMBL8043602 | 0.76 | GRM5 (0.54) | SMN1; SMN2RAB9AKMT2APPP1CAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | claimed |
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |