SCHEMBL8043774

SCHEMBL8043774

Cc1cc(O)n(C(C)N)c(=O)c1C#N

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 11/20 0.50
MEN1 O00255 5/20 0.46
KMT2A Q03164 5/20 0.46
MAPT P10636 3/20 0.46
THRB P10828 2/20 0.46
LMNA P02545 4/20 0.45
ALDH1A1 P00352 3/20 0.44
MAPK1 P28482 1/20 0.44
USP2 O75604 1/20 0.43
UPP1 Q16831 1/20 0.42
HPGD P15428 1/20 0.41
HSD17B10 Q99714 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11042949 0.87 KDM4E (0.53) KDM4EMEN1KMT2AMAPTTHRB
SCHEMBL4801774 0.85 KDM4E (0.55) KDM4EMEN1KMT2AMAPTTHRB
SCHEMBL11238064 0.83 KDM4E (0.49) KDM4EMEN1KMT2AMAPTTHRB
SCHEMBL5365754 0.83 KDM4E (0.49) KDM4EMEN1KMT2AMAPTTHRB
SCHEMBL11228910 0.81 KDM4E (0.48) KDM4EMEN1KMT2AMAPTTHRB
SCHEMBL10962110 0.81 KDM4E (0.51) KDM4EMEN1KMT2AMAPTTHRB
SCHEMBL11238059 0.78 KDM4E (0.58) KDM4EMEN1KMT2AMAPTTHRB
SCHEMBL14342067 0.78 KDM4E (0.48) KDM4EMEN1KMT2AMAPTTHRB
SCHEMBL11235934 0.78 KDM4E (0.45) KDM4EMEN1KMT2AMAPTTHRB
SCHEMBL11247380 0.77 ALDH1A1 (0.49) KDM4EMEN1KMT2AMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4032532-A AZO DYES SANDOZ LTD. (CH) 1977-06-28 US claimed
US-6046311-A Water-soluble fiber-reactive dyes, preparation thereof and use thereof DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2000-04-04 US disclosed
US-5731421-A COLORFASTNESS CIBA SPECIALTY CHEMICALS CORPORATION (US) 1998-03-24 US disclosed
US-5591834-A AZO, PHTHALOCYANINE, AND DIOXAZINE DYES FOR COTTON AND POLYAMIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-01-07 US disclosed
US-5530104-A SUITABLE FOR DYEING AND PRINTING O CELLULOSE-CONTAINING FIBER MATERIAL; GOOD COLORFASTNESS CIBA-GEIGY CORPORATION (US) 1996-06-25 US disclosed
US-5401277-A For cotton BAYER AKTIENGESELLSCHAFT (DE) 1995-03-28 US disclosed
US-5391718-A Suitable for dyeing and printing of cellulose containing fibers; good colorfastness CIBA-GEIGY CORPORATION (US) 1995-02-21 US disclosed
US-5378817-A FOR DYEING COTTON BAYER AKTIENGESELLSCHAFT (DE) 1995-01-03 US disclosed
US-5342927-A Containing 2,4-difluoropyrimidine group; wet fastness BAYER AKTIENGESELLSCHAFT (DE) 1994-08-30 US disclosed
US-5270454-A Reactive dyestuffs BAYER AKTIENGESELLSCHAFT (DE) 1993-12-14 US disclosed
US-4801694-A Triazinyl reactive dyestuffs in which triazinyl group is further substituted with a beta-chloroethylsulfonyl- or vinylsulfonylbutyrylamino moiety CIBA-GEIGY CORPORATION (US) 1989-01-31 US disclosed
US-4786721-A DYEING OR PRINTING CELLULOSE FIBERS CIBA-GEIGY CORPORATION (US) 1988-11-22 US disclosed
US-4766206-A Reactive dyestuffs comprising a vinylsulfonylalkylaminocarbonyl moiety CIBA-GEIGY CORPORATION (US) 1988-08-23 US disclosed
US-4746732-A COTTON AND WOOL CIBA-GEIGY CORPORATION (US) 1988-05-24 US disclosed
US-4713082-A Process for dyeing or printing textile fibre materials with reactive dye containing vinyl sulfonyl-type group and chloro-triazinyl amino group CIBA-GEIGY CORPORATION (US) 1987-12-15 US disclosed
US-4709018-A COLORFAST CIBA-GEIGY CORPORATION (US) 1987-11-24 US disclosed
US-4631065-A Reactive dyes, process for their preparation and use thereof CIBA-GEIGY CORPORATION (US) 1986-12-23 US disclosed
US-4327018-A Azo dyes and the production and use thereof CIBA-GEIGY CORPORATION (US) 1982-04-27 US disclosed
US-4032532-A AZO DYES SANDOZ LTD. (CH) 1977-06-28 US disclosed
US-3998803-A TEXTILES FIDELITY UNION TRUST COMPANY, EXECUTIVE TRUSTEE UNDER THE SANDOZ TRUST (US) 1976-12-21 US disclosed