Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 10/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044117 | 0.84 | BMP1 (0.46) | BMP1MMP1MMP2MMP9MMP8 | |
| SCHEMBL6412306 | 0.84 | BMP1 (0.54) | BMP1MMP1MMP2MMP9MMP8 | |
| SCHEMBL6411529 | 0.77 | BMP1 (0.53) | BMP1MMP1MMP2MMP9MMP8 | |
| SCHEMBL6421485 | 0.76 | BMP1 (0.53) | BMP1MMP1MMP2MMP9MMP8 | |
| SCHEMBL6412691 | 0.75 | BMP1 (0.47) | BMP1MMP1MMP2MMP9MMP8 | |
| SCHEMBL8037719 | 0.74 | BMP1 (0.56) | BMP1MMP1MMP2MMP9MMP8 | |
| SCHEMBL8027629 | 0.74 | BMP1 (0.56) | BMP1MMP1MMP2MMP9MMP8 | |
| SCHEMBL6417009 | 0.74 | BMP1 (0.53) | BMP1MMP1MMP2MMP9MMP8 | |
| SCHEMBL8041132 | 0.72 | BMP1 (0.58) | BMP1MMP1MMP2MMP9MMP8 | |
| SCHEMBL8038085 | 0.70 | BMP1 (0.69) | BMP1MMP1MMP9MMP13MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124329-A | AN ENZYME INHIBITOR FOR THE TREATMENT OR PROPHYLAXIS OF TISSUE BREAKDOWN, FOR EXAMPLE RHEUMATOID ARTHRITIS, OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR, MULTIPLE SCLEROSIS | BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) | 2000-09-26 | — | — | US | disclosed |
| EP-0766664-B1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 2000-04-05 | — | — | EP | disclosed |
| EP-0766664-A2 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-04-09 | — | — | EP | disclosed |
| WO-1995035275-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-12-28 | — | — | WO | disclosed |