Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 1.00 |
| ▸ | DRD3 | P35462 | 8/20 | 1.00 |
| ▸ | DRD4 | P21917 | 6/20 | 1.00 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.68 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.68 |
| ▸ | CA1 | P00915 | 3/20 | 0.65 |
| ▸ | CA2 | P00918 | 3/20 | 0.65 |
| ▸ | ACHE | P22303 | 3/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044480 | 1.00 | DRD2 (1.00) | DRD2DRD3DRD4MTNR1AMTNR1B | |
| SCHEMBL8044484 | 1.00 | DRD2 (1.00) | DRD2DRD3DRD4MTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL10849302 | 0.98 | DRD2 (0.97) | DRD2DRD3DRD4MTNR1AMTNR1B | |
| SCHEMBL4518779 | 0.89 | DRD2 (0.80) | DRD2DRD3DRD4MTNR1AMTNR1B | |
| SCHEMBL7543876 | 0.89 | DRD2 (0.80) | DRD2DRD3DRD4MTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL7543024 | 0.88 | DRD2 (0.78) | DRD2DRD3DRD4MTNR1AMTNR1B | |
| SCHEMBL2959295 | 0.88 | DRD2 (0.78) | DRD2DRD3DRD4MTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL7544278 | 0.88 | DRD2 (0.78) | DRD2DRD3DRD4MTNR1AMTNR1B | |
| SCHEMBL338363 | 0.87 | DRD2 (0.77) | DRD2DRD3DRD4MTNR1AMTNR1B | |
| SCHEMBL8394758 | 0.84 | DRD2 (1.00) | DRD2DRD3DRD4MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817767-B1 | BICYCLIC AMINE DERIVATIVES AND THEIR USE AS ANTI-PSYCHOTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-24 | — | — | EP | disclosed |
| US-6008219-A | Bicyclic amine derivatives and their use as anti-psychotic agents | SMITHKLINE BEECH P.L.C. (GB) | 1999-12-28 | — | — | US | disclosed |
| EP-0817767-A1 | BICYCLIC AMINE DERIVATIVES AND THEIR USE AS ANTI-PSYCHOTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1998-01-14 | — | — | EP | disclosed |
| WO-1996030333-A1 | BICYCLIC AMINE DERIVATIVES AND THEIR USE AS ANTI-PSYCHOTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1996-10-03 | — | — | WO | disclosed |