Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048815 | 0.82 | ANPEP (0.50) | KDM4ETDP1ALDH1A1ANPEPHPGD | |
| SCHEMBL24843252 | 0.76 | TSHR (0.41) | HTTGPR88 | |
| SCHEMBL11061356 | 0.76 | KDM4E (0.43) | KDM4EALDH1A1ANPEPHPGDHTT | |
| SCHEMBL24818707 | 0.76 | ANPEP (0.55) | KDM4ETDP1ALDH1A1ANPEPHPGD | |
| SCHEMBL10570075 | 0.76 | ANPEP (0.55) | KDM4ETDP1ALDH1A1ANPEPHPGD | |
| SCHEMBL22307595 | 0.76 | ANPEP (0.55) | KDM4ETDP1ALDH1A1ANPEPHPGD | |
| SCHEMBL11060437 | 0.76 | HPGD (0.45) | KDM4EALDH1A1ANPEPHPGDHTT | |
| SCHEMBL13999454 | 0.75 | TSHR (0.40) | HTTGPR88 | |
| SCHEMBL11306182 | 0.73 | ANPEP (0.60) | KDM4ETDP1ALDH1A1ANPEPHPGD | |
| SCHEMBL11061885 | 0.73 | KDM4E (0.41) | KDM4EALDH1A1HPGDLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |