Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | ADH1B | P00325 | 1/20 | 0.37 |
| ▸ | ADH1C | P00326 | 1/20 | 0.37 |
| ▸ | ADH1A | P07327 | 1/20 | 0.37 |
| ▸ | ADH4 | P08319 | 1/20 | 0.37 |
| ▸ | ADH7 | P40394 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6750513 | 0.85 | ADH1B (0.45) | HPGDADH1BADH1CADH1AADH4 | |
| SCHEMBL5864150 | 0.79 | HPGD (0.60) | HPGDADH1BADH1CADH1AADH4 | |
| SCHEMBL28164287 | 0.77 | CHRM2 (0.42) | HPGDCHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9036181 | 0.75 | HPGD (0.44) | HPGDADH1BADH1CADH1AADH4 | |
| SCHEMBL20657005 | 0.75 | ADH1B (0.39) | HPGDADH1BADH1CADH1AADH4 | |
| SCHEMBL10282655 | 0.73 | CHRM2 (0.47) | CHRM2CHRM4CHRM5CHRM3MAPT | |
| SCHEMBL1678544 | 0.73 | ADH1B (0.59) | HPGDCHRM2CHRM4CHRM5ADH1B | |
| SCHEMBL1679102 | 0.73 | ADH1B (0.59) | HPGDCHRM2CHRM4CHRM5ADH1B | |
| SCHEMBL1679033 | 0.73 | ADH1B (0.59) | HPGDCHRM2CHRM4CHRM5ADH1B | |
| SCHEMBL10013013 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |