Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | EED | O75530 | 1/20 | 0.30 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.30 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6124685 | 0.61 | EED (0.36) | EEDSUZ12EZH2 | |
| SCHEMBL17444501 | 0.59 | KCNJ1 (0.42) | — | |
| SCHEMBL17141386 | 0.59 | TSHR (0.40) | — | |
| SCHEMBL18773501 | 0.59 | ALOX5AP (0.39) | — | |
| SCHEMBL16201997 | 0.59 | MAPK14 (0.40) | — | |
| SCHEMBL16202003 | 0.58 | HSD17B10 (0.42) | — | |
| SCHEMBL512436 | 0.57 | MAPT (0.39) | — | |
| SCHEMBL17720574 | 0.56 | LMNA (0.50) | — | |
| SCHEMBL20094519 | 0.55 | PSEN1 (0.35) | EEDSUZ12EZH2 | |
| SCHEMBL16202016 | 0.55 | MAPK8 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009045314-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2009-04-09 | — | — | WO | disclosed |