Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043711 | 1.00 | DRD2 (0.61) | DRD2MEN1KMT2AGRM2ATM | |
| SCHEMBL8043716 | 1.00 | DRD2 (0.61) | DRD2MEN1KMT2AGRM2ATM | |
| SCHEMBL8042457 | 0.96 | DRD2 (0.63) | DRD2MEN1KMT2AGRM2ATM | |
| SCHEMBL8043603 | 0.91 | DRD2 (0.66) | DRD2MEN1KMT2AGRM2ATM | |
| SCHEMBL8042436 | 0.91 | DRD2 (0.66) | DRD2MEN1KMT2AGRM2ATM | |
| SCHEMBL8042432 | 0.91 | DRD2 (0.66) | DRD2MEN1KMT2AGRM2ATM | |
| SCHEMBL8041668 | 0.84 | DRD2 (0.57) | DRD2MEN1KMT2AGRM2ATM | |
| SCHEMBL4747037 | 0.83 | DRD2 (0.76) | DRD2MEN1KMT2AGRM2ATM | |
| SCHEMBL8041643 | 0.82 | DRD2 (0.59) | DRD2MEN1KMT2AGRM2ATM | |
| SCHEMBL8042461 | 0.82 | DRD2 (0.59) | DRD2MEN1KMT2AGRM2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6133275-A | ALPHA 1 ADRENORECEPTOR ANTAGONISTS; TREATING BENIGN PROSTATIC HYPERPLASIA AND OTHER UROLOGICAL DISEASES E.G., BLADDER OUTLET OBSTRUCTION), NEUROGENIC BLADDER AND GYNECOLOGICAL SYNDROMES, E.G., DYSMENORRHEA; UTERINE MUSCLE RELAXANTS | ABBOTT LABORATORIES (US) | 2000-10-17 | — | — | US | disclosed |
| WO-1999057122-A1 | 3-PHENYLPYRROLE ALPHA-1 ADRENERGIC COMPOUNDS | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |