Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA3 | P07451 | 2/20 | 0.41 |
| ▸ | CA6 | P23280 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1065627 | 0.84 | LMNA (0.55) | LMNATP53KDM4EHSD17B10CA12 | |
| SCHEMBL21612895 | 0.83 | PIM1 (0.60) | LMNAKDM4EHSD17B10CA12CA2 | |
| SCHEMBL1066544 | 0.82 | CA12 (0.55) | LMNATP53KDM4EHSD17B10CA12 | |
| SCHEMBL8056509 | 0.82 | LMNA (0.44) | LMNATP53KDM4EHSD17B10CA12 | |
| SCHEMBL3487931 | 0.81 | FLT3 (0.61) | LMNATP53KDM4EHSD17B10CA2 | |
| SCHEMBL29926214 | 0.78 | MAPT (0.60) | TP53HSD17B10ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL23486859 | 0.78 | PIM1 (0.41) | LMNATP53KDM4EHSD17B10PIM1 | |
| SCHEMBL5592937 | 0.77 | LMNA (0.65) | LMNATP53KDM4EHSD17B10CA12 | |
| SCHEMBL27349246 | 0.77 | PIM1 (0.71) | KDM4ECA2PIM1GAAFLT3 | |
| SCHEMBL9318977 | 0.76 | MAOB (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563475-B1 | Cell binding agent conjugates of derivatives of CC-1065 | IMMUNOGEN INC (US) | 2000-05-31 | — | — | EP | disclosed |
| US-5846545-A | Targeted delivery of cyclopropylbenzindole-containing cytotoxic drugs | IMMUNOGEN, INC. (US) | 1998-12-08 | — | — | US | disclosed |
| US-5585499-A | DRUG DELIVERY | IMMUNOGEN INC. (US) | 1996-12-17 | — | — | US | disclosed |
| US-5475092-A | Deliver cytotoxic drugs to specific cell population in targeted fashion | IMMUNOGEN INC. (US) | 1995-12-12 | — | — | US | disclosed |
| EP-0563475-A1 | Cell binding agent conjugates of derivatives of CC-1065 | IMMUNOGEN INC (US) | 1993-10-06 | — | — | EP | disclosed |