Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 7/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8723821 | 0.84 | TP53 (0.37) | TSHRALDH1A1MAPK1TP53LMNA | |
| SCHEMBL8057812 | 0.80 | NPC1 (0.40) | TSHRALDH1A1TP53LMNATBXAS1 | |
| SCHEMBL8517453 | 0.77 | TP53 (0.52) | TSHRALDH1A1MAPK1TP53LMNA | |
| SCHEMBL20141792 | 0.76 | POLB (0.57) | TSHRALDH1A1LMNAPOLBAPEX1 | |
| SCHEMBL30695197 | 0.76 | POLB (0.57) | TSHRALDH1A1LMNAPOLBAPEX1 | |
| SCHEMBL16938383 | 0.76 | POLB (0.74) | ALDH1A1LMNAPOLBNPC1RAB9A | |
| SCHEMBL31005447 | 0.76 | POLB (0.74) | ALDH1A1LMNAPOLBNPC1RAB9A | |
| SCHEMBL537743 | 0.72 | EHMT2 (0.59) | ALDH1A1POLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11457519 | 0.71 | TP53 (0.61) | TSHRALDH1A1MAPK1TP53LMNA | |
| SCHEMBL6163141 | 0.71 | PIM1 (0.70) | TSHRTP53LMNATBXAS1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563475-B1 | Cell binding agent conjugates of derivatives of CC-1065 | IMMUNOGEN INC (US) | 2000-05-31 | — | — | EP | disclosed |
| US-5846545-A | Targeted delivery of cyclopropylbenzindole-containing cytotoxic drugs | IMMUNOGEN, INC. (US) | 1998-12-08 | — | — | US | disclosed |
| US-5585499-A | DRUG DELIVERY | IMMUNOGEN INC. (US) | 1996-12-17 | — | — | US | disclosed |
| US-5475092-A | Deliver cytotoxic drugs to specific cell population in targeted fashion | IMMUNOGEN INC. (US) | 1995-12-12 | — | — | US | disclosed |
| EP-0563475-A1 | Cell binding agent conjugates of derivatives of CC-1065 | IMMUNOGEN INC (US) | 1993-10-06 | — | — | EP | disclosed |