SCHEMBL537743

SCHEMBL537743

c1ccc(CSSc2ccccn2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EHMT2 Q96KQ7 1/20 0.59
EHMT1 Q9H9B1 1/20 0.59
APOBEC3G Q9HC16 1/20 0.59
HSD17B10 Q99714 2/20 0.50
POLB P06746 1/20 0.49
MAPT P10636 3/20 0.46
NPC1 O15118 3/20 0.45
RAB9A P51151 3/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
KMT2A Q03164 2/20 0.45
MEN1 O00255 1/20 0.45
NFKB1 P19838 1/20 0.45
HTT P42858 1/20 0.45
NFKB2 Q00653 1/20 0.45
RELA Q04206 1/20 0.45
ALDH1A1 P00352 5/20 0.42
HPGD P15428 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
CYP2C9 P11712 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1126670 0.86 EHMT2 (0.52) EHMT2EHMT1APOBEC3GHSD17B10POLB
SCHEMBL10126383 0.86 EHMT2 (0.52) EHMT2EHMT1APOBEC3GHSD17B10POLB
SCHEMBL11957419 0.86 EHMT2 (0.52) EHMT2EHMT1APOBEC3GHSD17B10POLB
SCHEMBL31005447 0.84 POLB (0.74) EHMT2EHMT1APOBEC3GHSD17B10POLB
SCHEMBL16938383 0.84 POLB (0.74) EHMT2EHMT1APOBEC3GHSD17B10POLB
SCHEMBL12694344 0.82 ALDH1A1 (0.50) EHMT2EHMT1APOBEC3GPOLBMAPT
SCHEMBL20141792 0.81 POLB (0.57) EHMT2EHMT1APOBEC3GHSD17B10POLB
SCHEMBL12575545 0.81 EHMT2 (0.46) EHMT2EHMT1APOBEC3GHSD17B10POLB
SCHEMBL30695197 0.81 POLB (0.57) EHMT2EHMT1APOBEC3GHSD17B10POLB
SCHEMBL11978900 0.81 EHMT2 (0.46) EHMT2EHMT1APOBEC3GHSD17B10POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 278 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1126441-A Amplification of vitamin B12 absorption System Using polymers BIOTECH AUSTRALIA PTY LTD (AU) 1996-07-10 CN claimed
WO-2026042013-A1 MITOCHONDRIAL THERAPY INSTITUTE OF MOLECULAR AND CLINICAL OPHTHALMOLOGY BASEL (IOB) (CH) 2026-02-26 WO disclosed
US-20250361260-A1 NUCLEOTIDE ANALOGUES SINGULAR GENOMICS SYSTEMS INC (US) 2025-11-27 US disclosed
EP-4583890-A1 PROCESSES FOR GENERATING TIL PRODUCTS USING PD-1/TIGIT TALEN DOUBLE KNOCKDOWN Iovance Biotherapeutics, Inc. (US) 2025-07-16 EP disclosed
WO-2025137213-A1 FUSION PROTEINS COMPRISING ACID ALPHA-GLUCOSIDASE ENZYMES AND METHODS THEREOF DENALI THERAPEUTICS INC. (US) 2025-06-26 WO disclosed
US-12280021-B2 Affinity medicant conjugate AF CHEMICALS, LLC (US) 2025-04-22 US disclosed
US-12215122-B2 Nucleotide analogues Singular Genomics Systems, Inc. (US) 2025-02-04 US disclosed
US-20240400602-A1 NUCLEOTIDE ANALOGUES FIRST-CITIZENS BANK & TRUST COMPANY 2024-12-05 US disclosed
US-12145960-B2 Nucleotide analogues Singular Genomics Systems, Inc. (US) 2024-11-19 US disclosed
EP-4448746-A1 FUSION PROTEINS COMPRISING ALPHA-L-IDURONIDASE ENZYMES AND METHODS Denali Therapeutics Inc. (US) 2024-10-23 EP disclosed
EP-2193196-A2 ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME Portola Pharmaceuticals, Inc. (US) 2010-06-09 EP disclosed
WO-2010059861-A1 COMPOSITIONS AND METHODS TO MODULATE HAIR GROWTH UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2010-05-27 WO disclosed
WO-2010056765-A2 ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME IN COMBINATION WITH BLOOD COAGULATING AGENTS PORTOLA PHARMACEUTICALS, INC. (US) 2010-05-20 WO disclosed
WO-2009042962-A9 ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME PORTOLA PHARMACEUTICALS, INC. (US) 2009-09-11 WO disclosed
WO-2009079566-A2 NOVEL ADDL RECEPTOR POLYPEPTIDES, POLYNUCLEOTIDES AND HOST CELLS FOR RECOMBINANT PRODUCTION ACUMEN PHARMACEUTICALS, INC. (US) 2009-06-25 WO disclosed
WO-2009077438-A1 METHOD FOR PREPARING PROTEIN CONJUGATES GLAXOSMITHKLINE BIOLOGICALS S.A. (BE) 2009-06-25 WO disclosed
WO-2009042962-A2 ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME PORTOLA PHARMACEUTICALS, INC. (US) 2009-04-02 WO disclosed
WO-2004049800-A1 MAGNETIC MICROBICIDES HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2004-06-17 WO disclosed
CN-1230178-A Polydithiocarbamate-containing macromolecules and use thereof for therapeutic and diagnostic applications MEDINOX INC (US) 1999-09-29 CN disclosed
CN-1126441-A Amplification of vitamin B12 absorption System Using polymers BIOTECH AUSTRALIA PTY LTD (AU) 1996-07-10 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12280021-B2 Affinity medicant conjugate FCER2, HDGF, FCGR2A EHMT2 1488/4885EHMT1 1237/4885APOBEC3G 2830/4885
US-12215122-B2 Nucleotide analogues NUDT1, POLN, TYMP EHMT2 2494/4885EHMT1 2450/4885APOBEC3G 226/4885
US-20240400602-A1 NUCLEOTIDE ANALOGUES ADAR, NUDT1, NSUN2 EHMT2 938/4885EHMT1 923/4885APOBEC3G 236/4885
US-20250361260-A1 NUCLEOTIDE ANALOGUES ADAR, NUDT1, NSUN2 EHMT2 938/4885EHMT1 923/4885APOBEC3G 236/4885
US-12145960-B2 Nucleotide analogues ITPA, POLB, NUDT1 EHMT2 2878/4885EHMT1 3389/4885APOBEC3G 437/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.