Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | RPA1 | P27694 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1996494 | 0.84 | GRM5 (0.43) | GAAGRM5NPY5RLMNAMAPT | |
| SCHEMBL4189968 | 0.84 | MEN1 (0.48) | GAAGRM5LMNAMAPTMEN1 | |
| SCHEMBL1999421 | 0.78 | SMN1; SMN2 (0.48) | GAAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2889329 | 0.72 | GRM5 (0.45) | GAAGRM5LMNAMAPTMEN1 | |
| SCHEMBL2896761 | 0.71 | GRM5 (0.44) | GAAGRM5LMNAMAPTNPC1 | |
| SCHEMBL2002209 | 0.70 | GRM5 (0.46) | GAAGRM5LMNAMAPTMEN1 | |
| SCHEMBL2001185 | 0.70 | GRM5 (0.46) | GAAGRM5LMNAMAPTMEN1 | |
| SCHEMBL2962451 | 0.70 | PKM (0.51) | GAAGRM5LMNAMAPTSMN1; SMN2 | |
| SCHEMBL3115514 | 0.70 | GRM5 (0.46) | GAAGRM5LMNAMAPTMEN1 | |
| SCHEMBL2488620 | 0.69 | TLR8 (0.43) | GAAGRM5LMNAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009054790-A1 | AMIDE LINKED HETEROAROMATIC DERIVATIVES AS MODULATORS OF MGLUR5 | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | WO | disclosed |