Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
| ▸ | LSS | P48449 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8903864 | 1.00 | PPARD (0.44) | PPARDNPC1LMNAHTTGSK3B | |
| SCHEMBL8904544 | 0.83 | LSS (0.43) | PPARDLMNAHTTLSSMAPT | |
| SCHEMBL8047384 | 0.83 | LSS (0.43) | PPARDLMNAHTTLSSMAPT | |
| SCHEMBL3678869 | 0.82 | LSS (0.58) | PPARDLSS | |
| SCHEMBL8047705 | 0.82 | PPARD (0.38) | PPARDNPC1LMNAHTTSMPD1 | |
| SCHEMBL3678870 | 0.82 | LSS (0.58) | PPARDLSS | |
| SCHEMBL8045112 | 0.80 | PPARD (0.55) | PPARDGSK3BLSSRXRARXRB | |
| SCHEMBL8903933 | 0.80 | PPARD (0.55) | PPARDGSK3BLSSRXRARXRB | |
| SCHEMBL7688254 | 0.76 | LSS (0.39) | PPARDNPC1HTTLSSMAPT | |
| SCHEMBL7688257 | 0.76 | LSS (0.39) | PPARDNPC1HTTLSSMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636367-B1 | Use of phenylalkylamines for producing cholesterol lowering agents | HOFFMANN LA ROCHE (CH) | 2000-03-29 | — | — | EP | disclosed |
| US-5637771-A | Compound useful for lowering cholesterol | HOFFMANN-LA ROCHE INC. (US) | 1997-06-10 | — | — | US | disclosed |
| US-5574071-A | ADMINISTERING PHENYLALKYLAMINO KETONES | HOFFMANN-LA ROCHE INC. (US) | 1996-11-12 | — | — | US | disclosed |
| US-5495048-A | ANTICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| EP-0636367-A1 | Use of phenylalkylamines for producing cholesterol lowering agents | F. HOFFMANN-LA ROCHE AG (CH) | 1995-02-01 | — | — | EP | disclosed |