Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8052363 | 0.89 | TSHR (0.42) | HDAC1HDAC6RAB9ANPC1POLB | |
| SCHEMBL8050236 | 0.85 | HSD17B10 (0.43) | HDAC6RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL8032606 | 0.85 | HSD17B10 (0.43) | RAB9ANPC1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8044307 | 0.85 | HSD17B10 (0.47) | RAB9ANPC1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8050460 | 0.84 | HSD17B10 (0.42) | RAB9ANPC1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8051387 | 0.83 | HSD17B10 (0.41) | RAB9ANPC1POLBALDH1A1LMNA | |
| SCHEMBL8044290 | 0.82 | HSD17B10 (0.45) | RAB9ANPC1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8032467 | 0.81 | GSK3B (0.51) | HDAC6RAB9ANPC1POLBALDH1A1 | |
| SCHEMBL8042682 | 0.81 | HSD17B10 (0.44) | RAB9ANPC1POLBALDH1A1LMNA | |
| SCHEMBL8044890 | 0.79 | ATM (0.47) | RAB9ANPC1SRCCASP3SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |