Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045227 | 0.84 | KDM4E (0.46) | GSK3BGAAKDM4ESMN1; SMN2LMNA | |
| SCHEMBL8052363 | 0.82 | TSHR (0.42) | HDAC6LMNAALDH1A1PTGDR2POLB | |
| SCHEMBL8046229 | 0.81 | HDAC1 (0.44) | HDAC6KDM4ESMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL8044307 | 0.80 | HSD17B10 (0.47) | GSK3BGAAKDM4ESMN1; SMN2LMNA | |
| SCHEMBL8042478 | 0.79 | GAA (0.49) | GAAKDM4ESMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL8031866 | 0.79 | HSD17B10 (0.58) | GAAKDM4ESMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL11591241 | 0.78 | HSD17B10 (0.51) | GAAHDAC6KDM4ESMN1; SMN2LMNA | |
| SCHEMBL8044290 | 0.77 | HSD17B10 (0.45) | GSK3BGAAKDM4ESMN1; SMN2LMNA | |
| SCHEMBL1422234 | 0.77 | LMNA (0.74) | GAAKDM4ESMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL8050637 | 0.76 | HDAC6 (0.49) | GAAHDAC6KDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |